Inflammation and repair are interrelated processes mediated by common cytokines and growth factors. Mesenchymal-epithelial interactions and cross-talk are probably important in maintaining intestinal integrity and repair. Repair processes may involve exposure of previously inaccessible growth factor receptors or redistribution of receptorswithin surviving cells. A large number of growth factors have shown promise using in vitro and in vivo animal studies. However, the majorityhave failed to translate into benefit when tested in clinical trials. Despite the failure of many of the early clinical trials, our greater understanding of the fundamental processesunderlying the inflammatory and repair pathways is likely to be translated into novel therapies within the next few years.
|Original language||English (US)|
|Title of host publication||Inflammatory Bowel Disease|
|Subtitle of host publication||Translating basic science into clinical practice|
|Number of pages||12|
|State||Published - May 18 2010|
- Biological basis of healing and repair in remission and relapse
- Cytokines - component of normal defense process
- Epidermal growth factor (EGF) receptor ligand family
- Factors regulating mucosal repair and protecting from injury in intestine
- Gastrointestinal stem cells - stem cell "niche"
- Regulation of mucosal repair - subepithelial cell populations and stroma
- Vascular endothelial growth factor
ASJC Scopus subject areas