Biotin-Responsive Carboxylase Deficiency Associated with Subnormal Plasma and Urinary Biotin

Jess Thoene, Herman Baker, Makoto Yoshino, Lawrence Sweetman, Jess Thoene

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

AN increasing number of patients have been diagnosed as having biotin-responsive multiple carboxylase deficiency.1 2 3 4 5 6 7 8 This genetic disorder involves defects in the metabolism of biotin and produces deficiencies of at least three biotin-containing carboxylases: propionyl-CoA carboxylase (PCC), 3-methylcrotonyl-CoA carboxylase (MCC), and pyruvate carboxylase (PC). All patients have responded to oral administration of 10 mg or more of biotin per day, with normalization of the clinical and biochemical abnormalities. There appear to be two forms of the disorder: a neonatal form and a juvenile form. The neonatal form presents in the first weeks of life, with metabolic acidosis and ketosis and may. . .

Original languageEnglish (US)
Pages (from-to)817-820
Number of pages4
JournalNew England Journal of Medicine
Volume304
Issue number14
DOIs
StatePublished - Apr 2 1981
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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