Bladder tissue engineering

Irina Stanasel, Majid Mirzazadeh, John J. Smith

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

The bladder can lose the ability to store and empty effectively as a result of numerous conditions. When conservative methods to maximize patient safety and quality of life fail, surgical reconstruction of the bladder is usually considered. Augmentation cystoplasty can be performed with the use of the small bowel, large bowel, or less often, stomach. An alternative approach, tissue engineering, identifies the body's own potential for regeneration and supports this propensity with appropriate raw materials and growth factors so that the body's original structure and function may be restored. Tissue engineering can involve the use of a scaffold or matrix alone or of cell-seeded matrices. Harvesting cells and culturing them has become an important tool in tissue engineering. Multiple possibilities for sources of cells have been investigated, including stem cells and differentiated cells from organs other than the bladder; however, to date, autologous bladder cells remain the gold standard for culture and seeding.

Original languageEnglish (US)
Pages (from-to)593-599
Number of pages7
JournalUrologic Clinics of North America
Volume37
Issue number4
DOIs
StatePublished - Nov 1 2010

Keywords

  • Bladder regeneration
  • Stem cells
  • Tissue engineering

ASJC Scopus subject areas

  • Urology

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