Blood culture time to positivity in febrile infants with bacteremia

Eric A. Biondi, Matthew Mischler, Karen E. Jerardi, Angela M. Statile, Jason French, Rianna Evans, Vivian Lee, Clifford Chen, Carl Asche, Jinma Ren, Samir S. Shah

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Importance Blood cultures are often obtained as part of the evaluation of infants with fever and these infants are typically observed until their cultures are determined to have no growth. However, the time to positivity of blood culture results in this population is not known. Objective To determine the time to positivity of blood culture results in febrile infants admitted to a general inpatient unit. Design, Setting, and Participants Multicenter, retrospective, cross-sectional evaluation of blood culture time to positivity. Data were collected by community and academic hospital systems associated with the Pediatric Research in Inpatient Settings Network. The study included febrile infants 90 days of age or younger with bacteremia and without surgical histories outside of an intensive care unit. EXPOSURES Blood culture growing pathogenic bacteria. Main Outcomes and Measures Time to positivity and proportion of positive blood culture results that become positive more than 24 hours after placement in the analyzer. Results A total of 392 pathogenic blood cultures were included from 17 hospital systems across the United States. The mean (SD) time to positivity was 15.41 (8.30) hours. By 24 hours, 91%(95%CI, 88-93) had turned positive. By 36 and 48 hours, 96%(95%CI, 95-98) and 99%(95%CI, 97-100) had become positive, respectively. Conclusions and Relevance Most pathogens in febrile, bacteremic infants 90 days of age or younger hospitalized on a general inpatient unit will be identified within 24 hours of collection. These data suggest that inpatient observation of febrile infants for more than 24 hours may be unnecessary in most infants.

Original languageEnglish (US)
Pages (from-to)844-849
Number of pages6
JournalJAMA Pediatrics
Volume168
Issue number9
DOIs
StatePublished - Sep 1 2014

Fingerprint

Bacteremia
Fever
Inpatients
Community Hospital
Blood Culture
Intensive Care Units
Observation
Outcome Assessment (Health Care)
Pediatrics
Bacteria
Growth
Research
Population

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

Biondi, E. A., Mischler, M., Jerardi, K. E., Statile, A. M., French, J., Evans, R., ... Shah, S. S. (2014). Blood culture time to positivity in febrile infants with bacteremia. JAMA Pediatrics, 168(9), 844-849. https://doi.org/10.1001/jamapediatrics.2014.895

Blood culture time to positivity in febrile infants with bacteremia. / Biondi, Eric A.; Mischler, Matthew; Jerardi, Karen E.; Statile, Angela M.; French, Jason; Evans, Rianna; Lee, Vivian; Chen, Clifford; Asche, Carl; Ren, Jinma; Shah, Samir S.

In: JAMA Pediatrics, Vol. 168, No. 9, 01.09.2014, p. 844-849.

Research output: Contribution to journalArticle

Biondi, EA, Mischler, M, Jerardi, KE, Statile, AM, French, J, Evans, R, Lee, V, Chen, C, Asche, C, Ren, J & Shah, SS 2014, 'Blood culture time to positivity in febrile infants with bacteremia', JAMA Pediatrics, vol. 168, no. 9, pp. 844-849. https://doi.org/10.1001/jamapediatrics.2014.895
Biondi EA, Mischler M, Jerardi KE, Statile AM, French J, Evans R et al. Blood culture time to positivity in febrile infants with bacteremia. JAMA Pediatrics. 2014 Sep 1;168(9):844-849. https://doi.org/10.1001/jamapediatrics.2014.895
Biondi, Eric A. ; Mischler, Matthew ; Jerardi, Karen E. ; Statile, Angela M. ; French, Jason ; Evans, Rianna ; Lee, Vivian ; Chen, Clifford ; Asche, Carl ; Ren, Jinma ; Shah, Samir S. / Blood culture time to positivity in febrile infants with bacteremia. In: JAMA Pediatrics. 2014 ; Vol. 168, No. 9. pp. 844-849.
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