Bone Mineral Density Is Negatively Associated With Arterial Stiffness in Men With Hypertension

Xue Song Li; Hui He; Yi Lin Zhao; Ying Li; Zhi Ping Liu; Tiemin Liu; Yong Zhang; Kai Jiang Yu; Rui Tao Wang

doi:10.1111/jch.12848

Bone Mineral Density Is Negatively Associated With Arterial Stiffness in Men With Hypertension

Xue Song Li, Hui He, Yi Lin Zhao, Ying Li, Zhi Ping Liu, Tiemin Liu, Yong Zhang, Kai Jiang Yu, Rui Tao Wang

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Hypertension (HTN) and osteoporosis are associated with the development and progress of atherosclerosis. However, little research has been conducted to examine the relationship between arterial stiffness and bone mineral density (BMD) in men with HTN. This cross-sectional study recruited 355 men with HTN and 353 control patients without HTN. Brachial-ankle pulse wave velocity (baPWV) and BMD measurements were performed. BMD was decreased and baPWV was elevated in patients with HTN compared with control patients (femoral neck [FN] BMD in the HTN and control groups were 0.662±0.195 g/cm² and 0.713±0.204 g/cm², respectively [P=.001], and baPWV in the HTN and control groups were 1403.3±156.8 cm/s and 1354.8±136.0 cm/s, respectively [P<.001]). Multiple linear regression analysis demonstrated that FN BMD was negatively associated with increased baPWV in HTN. Reduced FN BMD may be an independent factor for baPWV in patients with HTN.

Original language	English (US)
Pages (from-to)	1106-1111
Number of pages	6
Journal	Journal of Clinical Hypertension
Volume	18
Issue number	11
DOIs	https://doi.org/10.1111/jch.12848
State	Published - Nov 1 2016

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Cardiology and Cardiovascular Medicine

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title = "Bone Mineral Density Is Negatively Associated With Arterial Stiffness in Men With Hypertension",

abstract = "Hypertension (HTN) and osteoporosis are associated with the development and progress of atherosclerosis. However, little research has been conducted to examine the relationship between arterial stiffness and bone mineral density (BMD) in men with HTN. This cross-sectional study recruited 355 men with HTN and 353 control patients without HTN. Brachial-ankle pulse wave velocity (baPWV) and BMD measurements were performed. BMD was decreased and baPWV was elevated in patients with HTN compared with control patients (femoral neck [FN] BMD in the HTN and control groups were 0.662±0.195 g/cm2 and 0.713±0.204 g/cm2, respectively [P=.001], and baPWV in the HTN and control groups were 1403.3±156.8 cm/s and 1354.8±136.0 cm/s, respectively [P<.001]). Multiple linear regression analysis demonstrated that FN BMD was negatively associated with increased baPWV in HTN. Reduced FN BMD may be an independent factor for baPWV in patients with HTN.",

author = "Li, {Xue Song} and Hui He and Zhao, {Yi Lin} and Ying Li and Liu, {Zhi Ping} and Tiemin Liu and Yong Zhang and Yu, {Kai Jiang} and Wang, {Rui Tao}",

note = "Funding Information: The authors wish to express their appreciation to all the study participants. This study was supported by Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Heilongjiang Province, China. Publisher Copyright: {\textcopyright}2016 Wiley Periodicals, Inc.",

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AU - Li, Xue Song

AU - He, Hui

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AU - Li, Ying

AU - Liu, Zhi Ping

AU - Liu, Tiemin

AU - Zhang, Yong

AU - Yu, Kai Jiang

AU - Wang, Rui Tao

N1 - Funding Information: The authors wish to express their appreciation to all the study participants. This study was supported by Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Heilongjiang Province, China. Publisher Copyright: ©2016 Wiley Periodicals, Inc.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Hypertension (HTN) and osteoporosis are associated with the development and progress of atherosclerosis. However, little research has been conducted to examine the relationship between arterial stiffness and bone mineral density (BMD) in men with HTN. This cross-sectional study recruited 355 men with HTN and 353 control patients without HTN. Brachial-ankle pulse wave velocity (baPWV) and BMD measurements were performed. BMD was decreased and baPWV was elevated in patients with HTN compared with control patients (femoral neck [FN] BMD in the HTN and control groups were 0.662±0.195 g/cm2 and 0.713±0.204 g/cm2, respectively [P=.001], and baPWV in the HTN and control groups were 1403.3±156.8 cm/s and 1354.8±136.0 cm/s, respectively [P<.001]). Multiple linear regression analysis demonstrated that FN BMD was negatively associated with increased baPWV in HTN. Reduced FN BMD may be an independent factor for baPWV in patients with HTN.

AB - Hypertension (HTN) and osteoporosis are associated with the development and progress of atherosclerosis. However, little research has been conducted to examine the relationship between arterial stiffness and bone mineral density (BMD) in men with HTN. This cross-sectional study recruited 355 men with HTN and 353 control patients without HTN. Brachial-ankle pulse wave velocity (baPWV) and BMD measurements were performed. BMD was decreased and baPWV was elevated in patients with HTN compared with control patients (femoral neck [FN] BMD in the HTN and control groups were 0.662±0.195 g/cm2 and 0.713±0.204 g/cm2, respectively [P=.001], and baPWV in the HTN and control groups were 1403.3±156.8 cm/s and 1354.8±136.0 cm/s, respectively [P<.001]). Multiple linear regression analysis demonstrated that FN BMD was negatively associated with increased baPWV in HTN. Reduced FN BMD may be an independent factor for baPWV in patients with HTN.

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Bone Mineral Density Is Negatively Associated With Arterial Stiffness in Men With Hypertension

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