Brain energy metabolism, cognitive function and down-regulated oxidative phosphorylation in Alzheimer disease

Stanley I. Rapoport, Kimmo Hatanpää, Daniel R. Brady, Krish Chandrasekaran

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Reduced brain glucose utilization in early stages of Alzheimer disease, as measured with in vivo positron emission tomography, reflects potentially reversible down-regulation of gene expression for oxidative phosphorylation within neuronal mitochondria. Such down-regulation may occur when neuronal energy demand is first reduced by synaptic dysfunction or loss.

Original languageEnglish (US)
Pages (from-to)473-476
Number of pages4
JournalNeurodegeneration
Volume5
Issue number4
DOIs
StatePublished - Dec 1996

Keywords

  • Alzheimer disease
  • Brain
  • Energy metabolism
  • Mitochondria
  • Oxidative phosphorylation
  • Positron emission tomography

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuropsychology and Physiological Psychology
  • Clinical Neurology

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