Brain lesions in patients with multiple sclerosis: Detection with echo-planar imaging

Bettina Siewert, Mahesh R. Patel, Markus F. Mueller, Jochen Gaa, David G. Darby, Charles M. Poser, Piotr A. Wielopolski, Robert R. Edelman, Steven Warach

Research output: Contribution to journalArticle

27 Scopus citations


PURPOSE: To evaluate the detection of brain lesions with echo-planar imaging relative to conventional spinecho (SE) imaging. MATERIALS AND METHODS: In 17 patients (three men, 14 women; mean age, 31 years) with multiple sclerosis, the following were compared: single-shot proton-density- and T2-weighted and thin-section T2-weighted echo-planar, proton-density- and T2-weighted multishot echo-planar, and conventional SE sequences. Quantitative and qualitative criteria as well as lesion detectability were evaluated. The proton-density-weighted SE sequence was used as the standard of reference. RESULTS: Multishot sequences were superior to single-shot sequences in image quality and lesion detectability. With the multishot proton-density-weighted sequence, 53 of 54 large lesions and 23 of 30 small lesions were detected; with the single-shot proton-density-weighted sequence, 38 of 54 large lesions and five of 30 small lesions were detected. CONCLUSION: With multishot echoplanar sequences, detectability of large lesions is similar to that with conventional SE imaging. Susceptibility artifact is diminished in comparison to single-shot echo-planar sequences.

Original languageEnglish (US)
Pages (from-to)765-771
Number of pages7
Issue number3
Publication statusPublished - Sep 1995



  • Brain neoplasms, MR, 10.121411, 10.121416
  • Magnetic resonance (MR), comparative studies, 10.121411, 10.121416
  • Magnetic resonance (MR), echo planar, 10.121416
  • Sclerosis, multiple, 10.871

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Siewert, B., Patel, M. R., Mueller, M. F., Gaa, J., Darby, D. G., Poser, C. M., ... Warach, S. (1995). Brain lesions in patients with multiple sclerosis: Detection with echo-planar imaging. Radiology, 196(3), 765-771.