Bridging multiple ontologies: Representation of the liver immune response

Anna Maria Masci, Jeffrey Roach, Bernard De Bono, Pierre Grenon, Lindsay Cowell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Chronic liver injury resulting in cirrhosis is the seventh leading cause of disease- related death in the USA. The liver immune response plays a key role in promoting, attenuating, and eventually resolving this severe condition. Although the liver immune response has been extensively investigated by conventional and omic approaches, gaps in knowledge still persist, and there is an urgent need for tools to facilitate the integration and analysis of these large, heterogeneous data sets. While ontologies are now accepted as an essential tool for data integration, no currently available ontology includes a representation of immunological reactions in the context of the liver. To address this need, we propose the Liver Immunology Ontology (LIO). LIO is being developed within the Open Biomedical Ontologies (OBO) Foundry framework, importing and linking relevant portions of orthogonal reference ontologies. LIO, is a novel tool for comprehensive analysis of liver immunology data sets, providing a valuable resource for the liver disease research community.

Original languageEnglish (US)
Title of host publicationCEUR Workshop Proceedings
Pages393-398
Number of pages6
Volume833
Publication statusPublished - 2011
Event2nd International Conference on Biomedical Ontology, ICBO 2011 - Buffalo, NY, United States
Duration: Jul 26 2011Jul 30 2011

Other

Other2nd International Conference on Biomedical Ontology, ICBO 2011
CountryUnited States
CityBuffalo, NY
Period7/26/117/30/11

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Keywords

  • Immunology
  • Liver diseases
  • OBO foundry
  • Ontology
  • OWL

ASJC Scopus subject areas

  • Computer Science(all)

Cite this

Masci, A. M., Roach, J., De Bono, B., Grenon, P., & Cowell, L. (2011). Bridging multiple ontologies: Representation of the liver immune response. In CEUR Workshop Proceedings (Vol. 833, pp. 393-398)