Btk function in B cell development and responsee

Anne B. Satterthwaite, Zuomei Li, Owen N. Witte

Research output: Contribution to journalArticle

142 Scopus citations

Abstract

Mutations in Bruton's tyrosine kinase (Btk) result in the B cell immunodeficiencies XLA in humans and Xid in mice. Both the maintenance of peripheral B cell numbers and their response to B cell antigen receptor (BCR) crosslinking depend on Btk. Btk integrates signals from multiple cell surface receptors, including BCR and G-protein coupled receptors. These Btk dependent signals control B cell proliferation and survival by mediating Ca2+ flux, activating JNK and p38 and inducing cell cycle regulatory genes.

Original languageEnglish (US)
Pages (from-to)309-316
Number of pages8
JournalSeminars in Immunology
Volume10
Issue number4
DOIs
StatePublished - Aug 1998

Keywords

  • B cell antigen receptor (BCR)
  • Bruton's tyrosine kinase (Btk)
  • Immunodeficiency
  • Pleckstrin homology (PH) domain
  • Tyrosine phosphorylation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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