Cachectin: More Than a Tumor Necrosis Factor

B. Beutler, A. Cerami

Research output: Contribution to journalReview article

1130 Scopus citations

Abstract

THE metabolic impact of infectious and neoplastic disease states has long been known to clinicians.1 2 3 4 Invasive diseases may disrupt normal homeo-static mechanisms, both locally and systemically. For example, acute gram-negative infections frequently lead to profound metabolic acidosis and to biphasic changes in plasma glucose concentration, both seen in the context of hypotension, disseminated intravascular coagulation, and widespread tissue injury.5 6 7 8 9 10 11 12 Chronic infectious diseases, as well as neoplastic diseases, may provoke a severe wasting diathesis, in which negative calorie and nitrogen balance lead to death despite the absence of a large parasite or tumor burden. It was once widely believed that invasive…

Original languageEnglish (US)
Pages (from-to)379-385
Number of pages7
JournalNew England Journal of Medicine
Volume316
Issue number7
DOIs
StatePublished - Feb 12 1987

ASJC Scopus subject areas

  • Medicine(all)

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