Caenorhabditis elegans as an emerging model for virus-host interactions

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Abstract

Since 1999, Caenorhabditis elegans has been extensively used to study microbe-host interactions due to its simple culture, genetic tractability, and susceptibility to numerous bacterial and fungal pathogens. In contrast, virus studies have been hampered by a lack of convenient virus infection models in nematodes. The recent discovery of a natural viral pathogen of C. elegans and development of diverse artificial infection models are providing new opportunities to explore virushost interplay in this powerful model organism.

Original languageEnglish (US)
Article numbere00509-17
JournalJournal of Virology
Volume91
Issue number23
DOIs
StatePublished - Dec 1 2017

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Keywords

  • Caenorhabditis elegans
  • Flock House virus
  • Innate immunity
  • Orsay virus
  • RNA interference
  • Vesicular stomatitis virus
  • Virus-host interactions

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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