Campylobacter jejuni: collective components promoting a successful enteric lifestyle

Peter M. Burnham, David R. Hendrixson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Campylobacter jejuni is the leading cause of bacterial diarrhoeal disease in many areas of the world. The high incidence of sporadic cases of disease in humans is largely due to its prevalence as a zoonotic agent in animals, both in agriculture and in the wild. Compared with many other enteric bacterial pathogens, C. jejuni has strict growth and nutritional requirements and lacks many virulence and colonization determinants that are typically used by bacterial pathogens to infect hosts. Instead, C. jejuni has a different collection of factors and pathways not typically associated together in enteric pathogens to establish commensalism in many animal hosts and to promote diarrhoeal disease in the human population. In this Review, we discuss the cellular architecture and structure of C. jejuni, intraspecies genotypic variation, the multiple roles of the flagellum, specific nutritional and environmental growth requirements and how these factors contribute to in vivo growth in human and avian hosts, persistent colonization and pathogenesis of diarrhoeal disease.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalNature Reviews Microbiology
DOIs
StateAccepted/In press - Jun 11 2018

Fingerprint

Campylobacter jejuni
Life Style
Nutritional Requirements
Symbiosis
Flagella
Zoonoses
Cellular Structures
Growth
Agriculture
Virulence
Intercellular Signaling Peptides and Proteins
Incidence
Population

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Campylobacter jejuni : collective components promoting a successful enteric lifestyle. / Burnham, Peter M.; Hendrixson, David R.

In: Nature Reviews Microbiology, 11.06.2018, p. 1-15.

Research output: Contribution to journalArticle

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