TY - JOUR
T1 - Can a point-of-care troponin I assay be as good as a central laboratory assay? A MIDAS investigation
AU - Peacock, W. Frank
AU - Diercks, Deborah
AU - Birkhahn, Robert
AU - Singer, Adam J.
AU - Hollander, Judd E.
AU - Nowak, Richard
AU - Safdar, Basmah
AU - Miller, Chadwick D.
AU - Peberdy, Mary
AU - Counselman, Francis
AU - Chandra, Abhinav
AU - Kosowsky, Joshua
AU - Neuenschwander, James
AU - Schrock, Jon
AU - Lee-Lewandrowski, Elizabeth
AU - Arnold, William
AU - Nagurney, John
N1 - Publisher Copyright:
© The Korean Society for Laboratory Medicine.
PY - 2016/9
Y1 - 2016/9
N2 - Background: We aimed to compare the diagnostic accuracy of the Alere Triage Cardio3 Tropinin I (TnI) assay (Alere, Inc., USA) and the PathFast cTnI-II (Mitsubishi Chemical Medience Corporation, Japan) against the central laboratory assay Singulex Erenna TnI assay (Singulex, USA). Methods: Using the Markers in the Diagnosis of Acute Coronary Syndromes (MIDAS) study population, we evaluated the ability of three different assays to identify patients with acute myocardial infarction (AMI). The MIDAS dataset, described elsewhere, is a prospective multicenter dataset of emergency department (ED) patients with suspected acute coronary syndrome (ACS) and a planned objective myocardial perfusion evaluation. Myocardial infarction (MI) was diagnosed by central adjudication. Results: The C-statistic with 95% confidence intervals (CI) for diagnosing MI by using a common population (n = 241) was 0.95 (0.91-0.99), 0.95 (0.91-0.99), and 0.93 (0.89-0.97) for the Triage, Singulex, and PathFast assays, respectively. Of samples with detectable troponin, the absolute values had high Pearson (RP) and Spearman (RS) correlations and were RP =0.94 and RS=0.94 for Triage vs Singulex, RP =0.93 and RS=0.85 for Triage vs PathFast, and RP =0.89 and RS=0.73 for PathFast vs Singulex. Conclusions: In a single comparative population of ED patients with suspected ACS, the Triage Cardio3 TnI, PathFast, and Singulex TnI assays provided similar diagnostic performance for MI.
AB - Background: We aimed to compare the diagnostic accuracy of the Alere Triage Cardio3 Tropinin I (TnI) assay (Alere, Inc., USA) and the PathFast cTnI-II (Mitsubishi Chemical Medience Corporation, Japan) against the central laboratory assay Singulex Erenna TnI assay (Singulex, USA). Methods: Using the Markers in the Diagnosis of Acute Coronary Syndromes (MIDAS) study population, we evaluated the ability of three different assays to identify patients with acute myocardial infarction (AMI). The MIDAS dataset, described elsewhere, is a prospective multicenter dataset of emergency department (ED) patients with suspected acute coronary syndrome (ACS) and a planned objective myocardial perfusion evaluation. Myocardial infarction (MI) was diagnosed by central adjudication. Results: The C-statistic with 95% confidence intervals (CI) for diagnosing MI by using a common population (n = 241) was 0.95 (0.91-0.99), 0.95 (0.91-0.99), and 0.93 (0.89-0.97) for the Triage, Singulex, and PathFast assays, respectively. Of samples with detectable troponin, the absolute values had high Pearson (RP) and Spearman (RS) correlations and were RP =0.94 and RS=0.94 for Triage vs Singulex, RP =0.93 and RS=0.85 for Triage vs PathFast, and RP =0.89 and RS=0.73 for PathFast vs Singulex. Conclusions: In a single comparative population of ED patients with suspected ACS, the Triage Cardio3 TnI, PathFast, and Singulex TnI assays provided similar diagnostic performance for MI.
KW - Diagnostic accuracy
KW - Emergency medicine
KW - Point-of-care
KW - Troponin
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U2 - 10.3343/alm.2016.36.5.405
DO - 10.3343/alm.2016.36.5.405
M3 - Article
C2 - 27374704
AN - SCOPUS:84978271579
SN - 2234-3806
VL - 36
SP - 405
EP - 412
JO - Annals of Laboratory Medicine
JF - Annals of Laboratory Medicine
IS - 5
ER -