Cancer associated isoenzyme of serum galactosyltransferase

M. M. Weiser, D. K. Podolsky, K. Isselbacher

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Galactosyltransferase activity was assayed in sera from 58 patients with various types of cancer. On discontinuous polyacrylamide gel electrophoresis a slow moving peak of galactosyltransferase activity (isoenzyme II) was found to be present in the serum of 43 of these patients in addition to the major isoenzyme I. Isoenzyme II was found in only 2 of 39 patients with various nonmalignant disorders and was not detected in the serum of 22 normal control subjects. There was no correlation between the presence of this electrophoretically distinct isoenzyme and total serum galactosyltransferase activity, alkaline phosphatase, levels of carcinoembryonic antigen, or blood type. However, patients with widespread metastases had significantly higher isoenzyme II levels than those with no metastases or with limited local spread. Further studies will be necessary to evaluate the clinical usefulness of this serum galactosyltransferase isoenzyme in the diagnosis and monitoring of patients with neoplastic disease.

Original languageEnglish (US)
Pages (from-to)1319-1322
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume73
Issue number4
StatePublished - 1976

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Galactosyltransferases
Isoenzymes
Serum
Neoplasms
Neoplasm Metastasis
Carcinoembryonic Antigen
Physiologic Monitoring
Alkaline Phosphatase
Polyacrylamide Gel Electrophoresis

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Cancer associated isoenzyme of serum galactosyltransferase. / Weiser, M. M.; Podolsky, D. K.; Isselbacher, K.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 73, No. 4, 1976, p. 1319-1322.

Research output: Contribution to journalArticle

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