Candidate dosimetric predictors of long-term swallowing dysfunction after oropharyngeal intensity-modulated radiotherapy

David L. Schwartz, Katherine Hutcheson, Denise Barringer, Susan L. Tucker, Merrill Kies, F. Christopher Holsinger, K. Kian Ang, William H. Morrison, David I. Rosenthal, Adam S. Garden, Lei Dong, Jan S. Lewin

Research output: Contribution to journalArticle

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Abstract

Purpose: To investigate long-term swallowing function in oropharyngeal cancer patients treated with intensity-modulated radiotherapy (IMRT), and to identify novel dose-limiting criteria predictive for dysphagia. Methods and Materials: Thirty-one patients with Stage IV oropharyngeal squamous carcinoma enrolled on a Phase II trial were prospectively evaluated by modified barium swallow studies at baseline, and 6, 12, and 24 months post-IMRT treatment. Candidate dysphagia-associated organs at risk were retrospectively contoured into original treatment plans. Twenty-one (68%) cases were base of tongue and 10 (32%) were tonsil. Stage distribution was T1 (12 patients), T2 (10), T3 (4), T4 (2), and TX (3), and N2 (24), N3 (5), and NX (2). Median age was 52.8 years (range, 42-78 years). Thirteen patients (42%) received concurrent chemotherapy during IMRT. Thirteen (42%) were former smokers. Mean dose to glottic larynx for the cohort was limited to 18 Gy (range, 6-39 Gy) by matching IMRT to conventional low-neck fields. Results: Dose-volume constraints (V30 < 65% and V35 < 35% for anterior oral cavity and V55 < 80% and V65 < 30% for high superior pharyngeal constrictors) predictive for objective swallowing dysfunction were identified by univariate and multivariate analyses. Aspiration and feeding tube dependence were observed in only 1 patient at 24 months. Conclusions: In the context of glottic laryngeal shielding, we describe candidate oral cavity and superior pharyngeal constrictor organs at risk and dose-volume constraints associated with preserved long-term swallowing function; these constraints are currently undergoing prospective validation. Strict protection of the glottic larynx via beam-split IMRT techniques promises to make chronic aspiration an uncommon outcome.

Original languageEnglish (US)
Pages (from-to)1356-1365
Number of pages10
JournalInternational Journal of Radiation Oncology Biology Physics
Volume78
Issue number5
DOIs
StatePublished - Dec 1 2010

Fingerprint

Intensity-Modulated Radiotherapy
Deglutition
radiation therapy
Tongue
constrictors
Organs at Risk
larynx
predictions
dosage
Deglutition Disorders
Larynx
organs
Mouth
cancer
Oropharyngeal Neoplasms
vacuum
cavities
tongue
Palatine Tonsil
Enteral Nutrition

Keywords

  • Dose-volume constraints
  • Dysphagia
  • Head and neck cancer
  • IMRT
  • Radiation
  • Swallowing
  • Toxicity

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research

Cite this

Candidate dosimetric predictors of long-term swallowing dysfunction after oropharyngeal intensity-modulated radiotherapy. / Schwartz, David L.; Hutcheson, Katherine; Barringer, Denise; Tucker, Susan L.; Kies, Merrill; Holsinger, F. Christopher; Ang, K. Kian; Morrison, William H.; Rosenthal, David I.; Garden, Adam S.; Dong, Lei; Lewin, Jan S.

In: International Journal of Radiation Oncology Biology Physics, Vol. 78, No. 5, 01.12.2010, p. 1356-1365.

Research output: Contribution to journalArticle

Schwartz, DL, Hutcheson, K, Barringer, D, Tucker, SL, Kies, M, Holsinger, FC, Ang, KK, Morrison, WH, Rosenthal, DI, Garden, AS, Dong, L & Lewin, JS 2010, 'Candidate dosimetric predictors of long-term swallowing dysfunction after oropharyngeal intensity-modulated radiotherapy', International Journal of Radiation Oncology Biology Physics, vol. 78, no. 5, pp. 1356-1365. https://doi.org/10.1016/j.ijrobp.2009.10.002
Schwartz, David L. ; Hutcheson, Katherine ; Barringer, Denise ; Tucker, Susan L. ; Kies, Merrill ; Holsinger, F. Christopher ; Ang, K. Kian ; Morrison, William H. ; Rosenthal, David I. ; Garden, Adam S. ; Dong, Lei ; Lewin, Jan S. / Candidate dosimetric predictors of long-term swallowing dysfunction after oropharyngeal intensity-modulated radiotherapy. In: International Journal of Radiation Oncology Biology Physics. 2010 ; Vol. 78, No. 5. pp. 1356-1365.
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abstract = "Purpose: To investigate long-term swallowing function in oropharyngeal cancer patients treated with intensity-modulated radiotherapy (IMRT), and to identify novel dose-limiting criteria predictive for dysphagia. Methods and Materials: Thirty-one patients with Stage IV oropharyngeal squamous carcinoma enrolled on a Phase II trial were prospectively evaluated by modified barium swallow studies at baseline, and 6, 12, and 24 months post-IMRT treatment. Candidate dysphagia-associated organs at risk were retrospectively contoured into original treatment plans. Twenty-one (68{\%}) cases were base of tongue and 10 (32{\%}) were tonsil. Stage distribution was T1 (12 patients), T2 (10), T3 (4), T4 (2), and TX (3), and N2 (24), N3 (5), and NX (2). Median age was 52.8 years (range, 42-78 years). Thirteen patients (42{\%}) received concurrent chemotherapy during IMRT. Thirteen (42{\%}) were former smokers. Mean dose to glottic larynx for the cohort was limited to 18 Gy (range, 6-39 Gy) by matching IMRT to conventional low-neck fields. Results: Dose-volume constraints (V30 < 65{\%} and V35 < 35{\%} for anterior oral cavity and V55 < 80{\%} and V65 < 30{\%} for high superior pharyngeal constrictors) predictive for objective swallowing dysfunction were identified by univariate and multivariate analyses. Aspiration and feeding tube dependence were observed in only 1 patient at 24 months. Conclusions: In the context of glottic laryngeal shielding, we describe candidate oral cavity and superior pharyngeal constrictor organs at risk and dose-volume constraints associated with preserved long-term swallowing function; these constraints are currently undergoing prospective validation. Strict protection of the glottic larynx via beam-split IMRT techniques promises to make chronic aspiration an uncommon outcome.",
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AU - Tucker, Susan L.

AU - Kies, Merrill

AU - Holsinger, F. Christopher

AU - Ang, K. Kian

AU - Morrison, William H.

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AU - Garden, Adam S.

AU - Dong, Lei

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