Cardiac perforation after device closure of atrial septal defects with the Amplatzer septal occluder

Abhay Divekar, Tidimogo Gaamangwe, Nasir Shaikh, Michael Raabe, John Ducas

Research output: Contribution to journalArticlepeer-review

215 Scopus citations

Abstract

Objectives: Amplatzer septal occluder (ASO)-associated cardiac perforation (CP) at our institution prompted this retrospective review. Background: Cardiac perforation is a rare complication after transcatheter atrial septal defect (ASD) closure. Methods: To identify CP after transcatheter ASD closure with ASO, cardiac events (CE) describing definite CP, hemopericardium, pericardial effusion, cardiovascular collapse, or sudden death were analyzed. Cardiac events were identified from published literature (MEDLINE), medical device regulating agencies in North America and the European Commission, and AGA Medical Corporation (Golden Valley, Minnesota). Institutional cases were reviewed. Cardiac events were defined as early (pre-discharge) or late (post-discharge). Results: Twenty-nine CEs were identified. Five were excluded because findings were inconclusive for device-related CP. Ten patients were <18 years of age. Late CEs occurred in 66.6%; 25% presented weeks later (longest, three years). Three deaths were reported. Cardiac perforation occurred predominantly in the anterosuperior atrial walls and/or adjacent aorta. Conclusions: Amplatzer septal occluder-associated CP uniquely involves the anterosuperior atrial walls and adjacent aorta. Pathophysiology remains poorly understood.

Original languageEnglish (US)
Pages (from-to)1213-1218
Number of pages6
JournalJournal of the American College of Cardiology
Volume45
Issue number8
DOIs
StatePublished - Apr 19 2005
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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