Cardiomyocyte death: Mechanisms and translational implications

M. Chiong, Z. V. Wang, Z. Pedrozo, D. J. Cao, R. Troncoso, M. Ibacache, A. Criollo, A. Nemchenko, J. A. Hill, S. Lavandero

Research output: Contribution to journalReview article

227 Scopus citations

Abstract

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Although treatments have improved, development of novel therapies for patients with CVD remains a major research goal. Apoptosis, necrosis, and autophagy occur in cardiac myocytes, and both gradual and acute cell death are hallmarks of cardiac pathology, including heart failure, myocardial infarction, and ischemia/reperfusion. Pharmacological and genetic inhibition of autophagy, apoptosis, or necrosis diminishes infarct size and improves cardiac function in these disorders. Here, we review recent progress in the fields of autophagy, apoptosis, and necrosis. In addition, we highlight the involvement of these mechanisms in cardiac pathology and discuss potential translational implications.

Original languageEnglish (US)
Article numbere244
JournalCell Death and Disease
Volume2
Issue number12
DOIs
StatePublished - Dec 2011

Keywords

  • Apoptosis
  • Autophagy
  • Cardiovascular diseases
  • Heart
  • Necrosis

ASJC Scopus subject areas

  • Immunology
  • Cellular and Molecular Neuroscience
  • Cell Biology
  • Cancer Research

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    Chiong, M., Wang, Z. V., Pedrozo, Z., Cao, D. J., Troncoso, R., Ibacache, M., Criollo, A., Nemchenko, A., Hill, J. A., & Lavandero, S. (2011). Cardiomyocyte death: Mechanisms and translational implications. Cell Death and Disease, 2(12), [e244]. https://doi.org/10.1038/cddis.2011.130