Cardioprotection in ischaemia-reperfusion injury

Novel mechanisms and clinical translation

Francisco Altamirano, Zhao Wang, Joseph A Hill

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

In recent decades, robust successes have been achieved in conquering the acutely lethal manifestations of heart disease. Nevertheless, the prevalence of heart disease, especially heart failure, continues to rise. Among the precipitating aetiologies, ischaemic disease is a leading cause of heart failure. In the context of ischaemia, the myocardium is deprived of oxygen and nutrients, which elicits a cascade of events that provokes cell death. This ischaemic insult is typically coupled with reperfusion, either spontaneous or therapeutically imposed, wherein blood supply is restored to the previously ischaemic tissue. While this intervention limits ischaemic injury, it triggers a new cascade of events that is also harmful, viz. reperfusion injury. In recent years, novel insights have emerged regarding mechanisms of ischaemia-reperfusion injury, and some hold promise as targets of therapeutic relevance. Here, we review a select number of these pathways, focusing on recent discoveries and highlighting prospects for therapeutic manipulation for clinical benefit. Journal compilation

Original languageEnglish (US)
Pages (from-to)3773-3788
Number of pages16
JournalJournal of Physiology
Volume593
Issue number17
DOIs
StatePublished - Sep 1 2015

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Reperfusion Injury
Heart Diseases
Heart Failure
Reperfusion
Myocardium
Cell Death
Ischemia
Oxygen
Food
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Physiology

Cite this

Cardioprotection in ischaemia-reperfusion injury : Novel mechanisms and clinical translation. / Altamirano, Francisco; Wang, Zhao; Hill, Joseph A.

In: Journal of Physiology, Vol. 593, No. 17, 01.09.2015, p. 3773-3788.

Research output: Contribution to journalArticle

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