Cardiorespiratory fitness and metabolic risk

Scott M Grundy, Carolyn E. Barlow, Stephen W. Farrell, Gloria L Vega, William L. Haskell

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The present study sought to evaluate the relation between cardiovascular risk factors and cardiorespiratory fitness (CRF) in a large population. Low CRF has been associated with increased total mortality and cardiovascular mortality. The mechanisms underlying greater cardiovascular mortality have not yet been determined. A series of cardiovascular risk factors were measured in 59,820 men and 22,192 women who had undergone determinations of CRF with maximal exercise testing. The risk factor profiles were segregated into 5 quintiles of CRF. With decreasing CRF, increases occurred in obesity, triglycerides, nonhigh-density lipoprotein cholesterol, triglyceride/high-density lipoprotein ratios, blood pressure, metabolic syndrome, diabetes, and cigarette smoking. Self-reported physical activity declined with decreasing levels of CRF. In conclusion, it appears likely that the enrichment of cardiovascular risk factors, especially metabolic risk factors, account for a portion of the increased cardiovascular mortality in low-fitness subjects. The mechanisms responsible for this enrichment in subjects with a low CRF represent a challenge for future research.

Original languageEnglish (US)
Pages (from-to)988-993
Number of pages6
JournalAmerican Journal of Cardiology
Volume109
Issue number7
DOIs
StatePublished - Apr 1 2012

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Mortality
HDL Cholesterol
Triglycerides
Exercise
Cardiorespiratory Fitness
Obesity
Smoking
Blood Pressure
Population

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cardiorespiratory fitness and metabolic risk. / Grundy, Scott M; Barlow, Carolyn E.; Farrell, Stephen W.; Vega, Gloria L; Haskell, William L.

In: American Journal of Cardiology, Vol. 109, No. 7, 01.04.2012, p. 988-993.

Research output: Contribution to journalArticle

Grundy, Scott M ; Barlow, Carolyn E. ; Farrell, Stephen W. ; Vega, Gloria L ; Haskell, William L. / Cardiorespiratory fitness and metabolic risk. In: American Journal of Cardiology. 2012 ; Vol. 109, No. 7. pp. 988-993.
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