@article{a12ae6b516db4ac18e0bce4b9e866f2d,
title = "Cardiovascular health and dementia incidence among older adults in Latin America: Results from the 10/66 study",
abstract = "Objectives: Growing evidence shows that cardiovascular health (CVH) is associated with brain health. Little is known about this topic among older adults in Latin America, where the number of people living with dementia is rising. This study aimed to assess the longitudinal association between CVH and dementia in six Latin American countries. Methods: We analyzed longitudinal data from the 10/66 study that included nondementia residents at baseline aged 65+ in six Latin American countries (n = 6447) and were followed up for 3 years. An index of modifiable CVH factors (ranging from 0 to 14) was calculated. Incident dementia was modeled using competing risk regression to adjust for risk of death. Results: The sample included 6.2% participants with poor (0-5), 81.0% with moderate (6-10), and 12.8% with ideal CVH (11-14). At follow-up, 9.4% had developed dementia and 13.1% had died. Compared with those with poor CVH, participants with moderate and ideal levels of CVH had a significantly lower risk of dementia in both the unadjusted (subhazard ratio for moderate, 0.77; ideal, 0.59) and adjusted models (moderate, 0.73; ideal, 0.66). Conclusion: Moderate and ideal levels of CVH in old age may protect against dementia incidence. These findings may inform health promotion efforts within dementia national plans adopted recently in some Latin American countries.",
keywords = "Latin America, cardiovascular health, competing risks, dementia, survival analysis",
author = "Jaime Perales-Puchalt and Vidoni, {Michelle L.} and {Llibre Rodr{\'i}guez}, Juan and Vidoni, {Eric D.} and Sandra Billinger and Jeffrey Burns and Ma{\"e}lenn Guerchet and Lee, {Min Jae}",
note = "Funding Information: Research reported in this publication was supported by the National Institute on Aging of the National Institutes of Health under Award Number P30AG035982. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This is a secondary analysis of data collected by the 10/66 Dementia Research Group (www.alz.co.uk/1066). The 10/66 DRG is led by Martin Prince at the Institute of Psychiatry, Psychology and Neuroscience, King's College London. The other principal investigators, data custodians, and responsible for research governance in each site are Juan Llibre Rodriguez (Cuba), Daisy Acosta (Dominican Republic), Mariella Guerra (Peru), Aquiles Salas (Venezuela), Ana Luisa Sosa (Mexico), K.?S. Jacob (Vellore, India), Joseph D. Williams (Chennai, India), Ivonne Jimenez (Puerto Rico), and Yueqin Huang (China). The 10/66 Dementia Research Group's research has been funded by the Wellcome Trust Health Consequences of Population Change Programme (GR066133?prevalence phase in Cuba and Brazil; GR080002?incidence phase in Peru, Mexico, Argentina, Cuba, Dominican Republic, Venezuela, and China), the World Health Organization (India, Dominican Republic, and China), the US Alzheimer's Association (IIRG-04-1286?Peru, Mexico, and Argentina), the Puerto Rico State Legislature (Puerto Rico), and FONACIT/CDCH/UCV (Venezuela). The authors are thankful to the 10/66 researchers, staff, and participants for making such important data available. Publisher Copyright: {\textcopyright} 2019 John Wiley & Sons, Ltd.",
year = "2019",
month = jul,
doi = "10.1002/gps.5107",
language = "English (US)",
volume = "34",
pages = "1041--1049",
journal = "International Journal of Geriatric Psychiatry",
issn = "0885-6230",
publisher = "John Wiley and Sons Ltd",
number = "7",
}