Carpatamides A-C, cytotoxic arylamine derivatives from a marine-derived streptomyces sp.

Peng Fu, Melissa Johnson, Hong Chen, Bruce A. Posner, John B. MacMillan

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Three new acylated arylamine derivatives (1-3), carpatamides A-C, were isolated from a marine-derived Streptomyces sp. based on activity screening against non-small-cell lung cancer (NSCLC). The structures of 1-3 were established on the basis of comprehensive spectroscopic analyses and chemical methods. Compounds 1 and 3 showed moderate cytotoxicity against NSCLC cell lines HCC366, A549, and HCC44 with IC50 values ranging from 2.2 to 8.4 μM.

Original languageEnglish (US)
Pages (from-to)1245-1248
Number of pages4
JournalJournal of Natural Products
Volume77
Issue number5
DOIs
StatePublished - May 23 2014

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Streptomyces
Non-Small Cell Lung Carcinoma
Cells
Derivatives
Cytotoxicity
Inhibitory Concentration 50
Screening
carpatamide C
carpatamide A
A549 Cells

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Analytical Chemistry
  • Organic Chemistry
  • Molecular Medicine
  • Complementary and alternative medicine

Cite this

Carpatamides A-C, cytotoxic arylamine derivatives from a marine-derived streptomyces sp. / Fu, Peng; Johnson, Melissa; Chen, Hong; Posner, Bruce A.; MacMillan, John B.

In: Journal of Natural Products, Vol. 77, No. 5, 23.05.2014, p. 1245-1248.

Research output: Contribution to journalArticle

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