Casein kinase I transduces Wnt signals

John M. Peters, Renée M. McKay, James P. McKay, Jonathan M. Graff

Research output: Contribution to journalArticlepeer-review

368 Scopus citations

Abstract

The Wnt signalling cascade is essential for the development of both invertebrates and vertebrates, and is altered during tumorigenesis. Although a general framework for Wnt signalling has been elucidated, not all of the components have been identified. Here we describe a serine kinase, casein kinase I (CKI), which was isolated by expression cloning in Xenopus embryos. CKI reproduces several properties of Wnt signals, including generation of complete dorsal axes, stabilization of β-catenin and induction of genes that are direct targets of Wnt signals. Dominant-negative forms of CKI and a pharmacological blocker of CKI inhibited Wnt signals in Xenopus. Inhibiting CKI in Caenorhabditis elegans generated worms with a more phenotype, indicative of a loss of Wnt signals. In addition, CKI bound to and increased the phosphorylation of dishevelled, a known component of the Wnt pathway. These data indicate that CKI may be a conserved component of the Wnt pathway.

Original languageEnglish (US)
Pages (from-to)345-350
Number of pages6
JournalNature
Volume401
Issue number6751
DOIs
StatePublished - Sep 23 1999

ASJC Scopus subject areas

  • General

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