Catechol-O-methyltransferase activity in erythrocytes of pregnant women

G. William Bates, Clare D. Edman, John C. Porter, Paul C. MacDonald

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Catechol-O-methyltransferase (COMT) is the enzyme that converts catechols, e.g., catecholamines and catechol estrogens, to their methyl ethers. COMT activity measured in erythrocytes (RBC's) of healthy men (No. = 47) and healthy nonpregnant women (No. = 53) was 8.2 ± 0.17 nmoles × ml.-1 (mean and standard error). The COMT activity in RBC's of healthy pregnant women (No. = 100) was 10.7 ± 0.29 nmoles × ml.-1 RBC × hr.-1, a value which is significantly higher than that found in RBC's of men and nonpregnant women (p < 0.001).

Original languageEnglish (US)
Pages (from-to)555-557
Number of pages3
JournalAmerican journal of obstetrics and gynecology
Volume131
Issue number5
DOIs
StatePublished - Jul 1 1978

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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