Catechol-O-methyltransferase activity in erythrocytes of pregnant women

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13 Scopus citations


Catechol-O-methyltransferase (COMT) is the enzyme that converts catechols, e.g., catecholamines and catechol estrogens, to their methyl ethers. COMT activity measured in erythrocytes (RBC's) of healthy men (No. = 47) and healthy nonpregnant women (No. = 53) was 8.2 ± 0.17 nmoles × ml.-1 (mean and standard error). The COMT activity in RBC's of healthy pregnant women (No. = 100) was 10.7 ± 0.29 nmoles × ml.-1 RBC × hr.-1, a value which is significantly higher than that found in RBC's of men and nonpregnant women (p < 0.001).

Original languageEnglish (US)
Pages (from-to)555-557
Number of pages3
JournalAmerican Journal of Obstetrics and Gynecology
Issue number5
Publication statusPublished - Jul 1 1978


ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Bates, G. W., Edman, C. D., Porter, J. C., & MacDonald, P. C. (1978). Catechol-O-methyltransferase activity in erythrocytes of pregnant women. American Journal of Obstetrics and Gynecology, 131(5), 555-557.