Caveolin-I overexpression is associated with aggressive prostate cancer recurrence

Jose A. Karam, Yair Lotan, Claus Roehrborn, Raheela Ashfaq, Pierre I. Karakiewicz, Shahrokh F. Shariat

Research output: Contribution to journalArticle

116 Scopus citations

Abstract

BACKGROUND. Caveolin-1 protein suppresses apoptotic cell death in prostate cancer. The objectives of this study were to investigate the association of Caveolin-1 expression with established features of prostate cancer as well as overall and aggressive disease recurrence in patients treated with radical prostatectomy (RP). METHODS. Caveolin-1 immunostaining was performed on a tissue microarray containing prostatectomy specimen cores from 232 consecutive patients treated with RP for clinically localized prostatic adenocarcinoma. Caveolin-1 over-expression was defined as more than 50% of cells staining positively for Caveolin-1. Patients were categorized as having features of aggressive disease recurrence if they had a positive metastatic work-up, post-recurrence PSA doubling time less than 10 months, and/or failure to respond to local salvage radiation therapy. RESULTS. Seventy patients (30.2%) exhibited over-expression of Caveolin-1. Caveolin-1 overexpression was associated with higher pathologic Gleason sum (P = 0.038) and higher pre-operative PSA level (P = 0.024). Patients with Caveolin-1 over-expression were at increased risk of PSA recurrence after surgery (P = 0.023) in univariate but not in standard post-operative multivariate analysis. However, patients with Caveolin-1 over-expression were at increased risk of aggressive prostate cancer recurrence in both univariate and multivariate analysis (P < 0.001 and P = 0.001, respectively). CONCLUSIONS. Over-expression of Caveolin-1 was associated with established features of prostate cancer and aggressive PSA recurrence. Caveolin-1 might help identify patients at high risk of developing aggressive prostate cancer recurrence, thus allowing selection of patients who might benefit from early systemic therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)614-622
Number of pages9
JournalProstate
Volume67
Issue number6
DOIs
StatePublished - May 1 2007

Keywords

  • Caveolin-1
  • Prostatic neoplasms
  • Radical prostatectomy
  • Recurrence
  • Stage

ASJC Scopus subject areas

  • Oncology
  • Urology

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