(matrix presented) A new 36-membered macrolactone, (25S,27S,29S,33S)-caylobolided A, was isolated from the Bahamian cyanobacterium Lyngbya majuscula. The structure of caylobolide contains an unprecedented repeated unit - a contiguous pentad of 1,5 diols - and a 1,3,5-triol. The relative stereochemistry of the 1,3,5-triol was determined using Kishi's Universal NMR database, and absolute stereochemistry at C25,27,29 and C33 were determined by Mosher's analysis. Caylobolide A exhibited in vitro cytotoxicity against human colon tumor cells (IC50 HCT 116, 9.9 μM).
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry