cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12

Christine Kim Garcia; Xu Li; Jac Luna; Uta Francke

doi:10.1006/geno.1994.1532

cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12

Christine Kim Garcia, Xu Li, Jac Luna, Uta Francke

Research output: Contribution to journal › Article › peer-review

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Abstract

Lactate and pyruvate are transported across cell membranes by monocarboxylate transporters (MCTs). Here, we use the recently cloned DNA for hamster MCT1 to isolate cDNA and genomic clones for human MCT1. Comparison of the human and hamster amino acid sequences revealed that the proteins are 86% identical. The gene for human MCT1 (gene symbol, SLC16A1) was localized to human chromosome bands 1p13.2-p12 by PCR analysis of panels of human × rodent cell hybrid lines and by fluorescence chromosomal in situ hybridization.

Original language	English (US)
Pages (from-to)	500-503
Number of pages	4
Journal	Genomics
Volume	23
Issue number	2
DOIs	https://doi.org/10.1006/geno.1994.1532
State	Published - Sep 15 1994

ASJC Scopus subject areas

Genetics

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10.1006/geno.1994.1532

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abstract = "Lactate and pyruvate are transported across cell membranes by monocarboxylate transporters (MCTs). Here, we use the recently cloned DNA for hamster MCT1 to isolate cDNA and genomic clones for human MCT1. Comparison of the human and hamster amino acid sequences revealed that the proteins are 86% identical. The gene for human MCT1 (gene symbol, SLC16A1) was localized to human chromosome bands 1p13.2-p12 by PCR analysis of panels of human × rodent cell hybrid lines and by fluorescence chromosomal in situ hybridization.",

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AU - Li, Xu

AU - Luna, Jac

AU - Francke, Uta

PY - 1994/9/15

Y1 - 1994/9/15

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AB - Lactate and pyruvate are transported across cell membranes by monocarboxylate transporters (MCTs). Here, we use the recently cloned DNA for hamster MCT1 to isolate cDNA and genomic clones for human MCT1. Comparison of the human and hamster amino acid sequences revealed that the proteins are 86% identical. The gene for human MCT1 (gene symbol, SLC16A1) was localized to human chromosome bands 1p13.2-p12 by PCR analysis of panels of human × rodent cell hybrid lines and by fluorescence chromosomal in situ hybridization.

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cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12

Abstract

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