Cefdinir pharmacokinetics and tolerability in children receiving 25 mg/kg once daily

Karen L. Bowlware, George H. McCracken, Juanita Lozano-Hernandez, Faryal Ghaffar

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Of several oral cephalosporins, cefdinir is recommended as an alternative therapy for children with acute otitis media who have type 1 hypersensitivity to β-lactams. Because the current cefdinir dosage of 14 mg/kg/d is approved for treatment of acute otitis media caused by penicillin-susceptible Streptococcus pneumoniae, we hypothesized that a 25-mg/kg dose given daily would be more effective for nonsusceptible S. pneumoniae. Methods: We performed pharmacokinetic analyses on 37 infants and children who were given cefdinir in dosages of 14 or 25 mg/kg once daily for 10 days, for the treatment of respiratory and skin or skin structure infections. Cefdinir plasma concentrations were determined with validated liquid chromatology, and pharmacokinetics and pharmacodynamics were determined in relation to the minimum inhibitory concentration values of S. pneumoniae. Results: The maximal plasma concentrations and area-under-the-curve values were significantly higher after the 25-mg/kg in relation to the minimum inhibitory concentration values for S. pneumoniae strains. The pharmacodynamics measure of bacteriologic effectiveness was <40% of the dosing interval (ie, 24 hours), indicating that many of the penicillin-nonsusceptible S. pneumoniae causing acute otitis media would not be effectively treated. Diarrhea occurred in 20% of the 39 subjects that received the larger dosage of cefdinir. Conclusion: A cefdinir dosage of 25 mg/kg daily would be ineffective for treatment of acute otitis media caused by penicillin-nonsusceptible S. pneumoniae strain.

Original languageEnglish (US)
Pages (from-to)208-210
Number of pages3
JournalPediatric Infectious Disease Journal
Volume25
Issue number3
DOIs
StatePublished - Mar 2006

Fingerprint

cefdinir
Streptococcus pneumoniae
Pharmacokinetics
Otitis Media
Penicillins
Microbial Sensitivity Tests
Immediate Hypersensitivity
Lactams
Skin
Cephalosporins
Complementary Therapies
Area Under Curve
Diarrhea
Therapeutics

Keywords

  • Cefdinir
  • Pharmacokinetics
  • Tolerability

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)

Cite this

Cefdinir pharmacokinetics and tolerability in children receiving 25 mg/kg once daily. / Bowlware, Karen L.; McCracken, George H.; Lozano-Hernandez, Juanita; Ghaffar, Faryal.

In: Pediatric Infectious Disease Journal, Vol. 25, No. 3, 03.2006, p. 208-210.

Research output: Contribution to journalArticle

Bowlware, Karen L. ; McCracken, George H. ; Lozano-Hernandez, Juanita ; Ghaffar, Faryal. / Cefdinir pharmacokinetics and tolerability in children receiving 25 mg/kg once daily. In: Pediatric Infectious Disease Journal. 2006 ; Vol. 25, No. 3. pp. 208-210.
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