Cefoperazone and cefoxitin prophylaxis for abdominal hysterectomy

D. L. Hemsell, E. R. Johnson, R. E. Bawdon, P. G. Hemsell, M. L. Heard, B. J. Nobles

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16 Scopus citations

Abstract

One hundred one women undergoing elective abdominal hysterectomy were given perioperative cefoperazone or cefoxitin in a prospective randomized blinded study. Both regimens were well tolerated and no significant toxic or allergic manifestations were observed. Interrelationships between antimicrobial concentration in serum and pelvic tissues, intraoperative cardinal ligament cultures, febrile morbidity, and major postoperative infection were determined. At uterine removal, mean cefoperazone concentrations in serum (56.1µg/mL) and pelvic tissues (18.6 n-g/g) were significantly higher than mean concentrations of cefoxitin, ie, 16.1 µg/mL and 8.1 µg/g, respectively (P<.001). The incidence of major postoperative infection was 6% or less with both regimens. Perioperative prophylaxis significantly reduced the incidence of this infection. When it did develop, however, it continued to cause significant morbidity, prolonging hospital stay a mean of more than four days (P<.001) and increasing the hospital bill a mean of almost $1500 (P<.001).

Original languageEnglish (US)
Pages (from-to)467-472
Number of pages6
JournalObstetrics and gynecology
Volume63
Issue number4
StatePublished - Apr 1984

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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