Cell-Free Ligand Binding Assays for Nuclear Receptors

Stacey A. Jones, Derek J. Parks, Steven A. Kliewer

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

There has been tremendous progress in the development of ligand binding assays for NRs during the past several years. A major development has been the advent of homogeneous assay formats, including those that do not require a radioligand. These high throughput, low volume assay formats will be powerful tools for the identification and characterization of novel NR ligands, including both natural ligands for orphan NRs and new drugs that mediate their therapeutic effects through this class of receptors.

Original languageEnglish (US)
Pages (from-to)53-71
Number of pages19
JournalMethods in Enzymology
Volume364
DOIs
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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