Cell motility resulting from spontaneous polymerization waves

K. Doubrovinski, K. Kruse

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The crawling of cells on a substrate is in many cases driven by the actin cytoskeleton. How actin filaments and associated proteins are organized to generate directed motion is still poorly understood. Recent experimental observations suggest that spontaneous cytoskeletal waves might orchestrate the actin-filament network to produce directed motion. We investigate this possibility by studying a mean-field description of treadmilling filaments interacting with nucleating proteins, a system that is known to self-organize into waves. Confining the system by a boundary that shares essential features of membranes, we find that spontaneous waves can generate directional motion. We also find that it can produce lateral waves along the confining membrane as are observed in spreading cells.

Original languageEnglish (US)
Article number258103
JournalPhysical Review Letters
Volume107
Issue number25
DOIs
StatePublished - Dec 16 2011

Fingerprint

locomotion
polymerization
filaments
cells
confining
membranes
proteins

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Cell motility resulting from spontaneous polymerization waves. / Doubrovinski, K.; Kruse, K.

In: Physical Review Letters, Vol. 107, No. 25, 258103, 16.12.2011.

Research output: Contribution to journalArticle

@article{f1f610d9a60540eeba124046f518881b,
title = "Cell motility resulting from spontaneous polymerization waves",
abstract = "The crawling of cells on a substrate is in many cases driven by the actin cytoskeleton. How actin filaments and associated proteins are organized to generate directed motion is still poorly understood. Recent experimental observations suggest that spontaneous cytoskeletal waves might orchestrate the actin-filament network to produce directed motion. We investigate this possibility by studying a mean-field description of treadmilling filaments interacting with nucleating proteins, a system that is known to self-organize into waves. Confining the system by a boundary that shares essential features of membranes, we find that spontaneous waves can generate directional motion. We also find that it can produce lateral waves along the confining membrane as are observed in spreading cells.",
author = "K. Doubrovinski and K. Kruse",
year = "2011",
month = "12",
day = "16",
doi = "10.1103/PhysRevLett.107.258103",
language = "English (US)",
volume = "107",
journal = "Physical Review Letters",
issn = "0031-9007",
publisher = "American Physical Society",
number = "25",

}

TY - JOUR

T1 - Cell motility resulting from spontaneous polymerization waves

AU - Doubrovinski, K.

AU - Kruse, K.

PY - 2011/12/16

Y1 - 2011/12/16

N2 - The crawling of cells on a substrate is in many cases driven by the actin cytoskeleton. How actin filaments and associated proteins are organized to generate directed motion is still poorly understood. Recent experimental observations suggest that spontaneous cytoskeletal waves might orchestrate the actin-filament network to produce directed motion. We investigate this possibility by studying a mean-field description of treadmilling filaments interacting with nucleating proteins, a system that is known to self-organize into waves. Confining the system by a boundary that shares essential features of membranes, we find that spontaneous waves can generate directional motion. We also find that it can produce lateral waves along the confining membrane as are observed in spreading cells.

AB - The crawling of cells on a substrate is in many cases driven by the actin cytoskeleton. How actin filaments and associated proteins are organized to generate directed motion is still poorly understood. Recent experimental observations suggest that spontaneous cytoskeletal waves might orchestrate the actin-filament network to produce directed motion. We investigate this possibility by studying a mean-field description of treadmilling filaments interacting with nucleating proteins, a system that is known to self-organize into waves. Confining the system by a boundary that shares essential features of membranes, we find that spontaneous waves can generate directional motion. We also find that it can produce lateral waves along the confining membrane as are observed in spreading cells.

UR - http://www.scopus.com/inward/record.url?scp=83655202697&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=83655202697&partnerID=8YFLogxK

U2 - 10.1103/PhysRevLett.107.258103

DO - 10.1103/PhysRevLett.107.258103

M3 - Article

C2 - 22243118

AN - SCOPUS:83655202697

VL - 107

JO - Physical Review Letters

JF - Physical Review Letters

SN - 0031-9007

IS - 25

M1 - 258103

ER -