Cell of origin and cancer stem cells in tumor suppressor mouse models of glioblastoma

Sheila R. Alcantara Llaguno, Xuanhua Xie, Luis F. Parada

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The cellular origins and the mechanisms of progression, maintenance of tumorigenicity, and therapeutic resistance are central questions in the glioblastoma multiforme (GBM) field. Using tumor suppressor mouse models, our group recently reported two independent populations of adult GBM-initiating central nervous system progenitors. We found different functional and molecular subtypes depending on the tumor-initiating cell lineage, indicating that the cell of origin is a driver of GBMsubtype diversity. Using an in vivo model, we also showed that GBM cancer stem cells (CSCs) or glioma stem cells (GSCs) contribute to resistance to chemotherapeutic agents and that genetic ablation of GSCs leads to a delay in tumor progression. These studies are consistent with the cell of origin and CSCs as critical regulators of the pathogenesis of GBM.

Original languageEnglish (US)
Pages (from-to)31-36
Number of pages6
JournalCold Spring Harbor Symposia on Quantitative Biology
Volume81
Issue number1
DOIs
StatePublished - 2016

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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