TY - JOUR
T1 - Cell of origin of glioma
T2 - Biological and clinical implications
AU - Llaguno, Sheila R Alcantara
AU - Parada, Luis F.
N1 - Publisher Copyright:
© 2016 Cancer Research UK. All rights reserved.
PY - 2016/12/6
Y1 - 2016/12/6
N2 - The cellular origin of gliomas remains a topic of controversy in cancer research. Advances in neurobiology, molecular genetics, and functional genomics have ushered new insights through exploiting the development of more sophisticated tools to address this question. Diverse distinct cell populations in the adult brain have been reported to give rise to gliomas, although how these studies relate physiologically to mechanisms of spontaneous tumour formation via accumulation of tumour-initiating mutations within a single cell are less well developed. Recent studies in animal models indicate that the lineage of the tumour-initiating cell may contribute to the biological and genomic phenotype of glioblastoma. These results suggest that the cell of origin may not only serve as a source of diversity for these tumours, but may also provide new avenues for improved diagnostics and therapeutic targeting that may prolong the lives of patients.
AB - The cellular origin of gliomas remains a topic of controversy in cancer research. Advances in neurobiology, molecular genetics, and functional genomics have ushered new insights through exploiting the development of more sophisticated tools to address this question. Diverse distinct cell populations in the adult brain have been reported to give rise to gliomas, although how these studies relate physiologically to mechanisms of spontaneous tumour formation via accumulation of tumour-initiating mutations within a single cell are less well developed. Recent studies in animal models indicate that the lineage of the tumour-initiating cell may contribute to the biological and genomic phenotype of glioblastoma. These results suggest that the cell of origin may not only serve as a source of diversity for these tumours, but may also provide new avenues for improved diagnostics and therapeutic targeting that may prolong the lives of patients.
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U2 - 10.1038/bjc.2016.354
DO - 10.1038/bjc.2016.354
M3 - Review article
C2 - 27832665
AN - SCOPUS:84994689560
SN - 0007-0920
VL - 115
SP - 1445
EP - 1450
JO - British journal of cancer
JF - British journal of cancer
IS - 12
ER -