TY - JOUR
T1 - Cellular Metabolism and Induced Pluripotency
AU - Wu, Jun
AU - Ocampo, Alejandro
AU - Belmonte, Juan Carlos Izpisua
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/9/8
Y1 - 2016/9/8
N2 - The discovery of induced pluripotent stem cells (iPSCs) a decade ago, which we are celebrating in this issue of Cell, represents a landmark discovery in biomedical research. Together with somatic cell nuclear transfer, iPSC generation reveals the remarkable plasticity associated with differentiated cells and provides an unprecedented means for modeling diseases using patient samples. In addition to transcriptional and epigenetic remodeling, cellular reprogramming to pluripotency is also accompanied by a rewiring of metabolic pathways, which ultimately leads to changes in cell identities.
AB - The discovery of induced pluripotent stem cells (iPSCs) a decade ago, which we are celebrating in this issue of Cell, represents a landmark discovery in biomedical research. Together with somatic cell nuclear transfer, iPSC generation reveals the remarkable plasticity associated with differentiated cells and provides an unprecedented means for modeling diseases using patient samples. In addition to transcriptional and epigenetic remodeling, cellular reprogramming to pluripotency is also accompanied by a rewiring of metabolic pathways, which ultimately leads to changes in cell identities.
UR - http://www.scopus.com/inward/record.url?scp=84986328539&partnerID=8YFLogxK
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U2 - 10.1016/j.cell.2016.08.008
DO - 10.1016/j.cell.2016.08.008
M3 - Review article
C2 - 27610564
AN - SCOPUS:84986328539
SN - 0092-8674
VL - 166
SP - 1371
EP - 1385
JO - Cell
JF - Cell
IS - 6
ER -