Cellular responses to excess fatty acids: Focus on ubiquitin regulatory X domain-containing protein 8

Hyeonwoo Kim, Jin Ye

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

PURPOSE OF REVIEW: Although fatty acids are crucial for cell survival, their overaccumulation triggers lipotoxicity that leads to metabolic syndrome. Thus, cells maintain their homeostasis by multiple feedback regulatory systems. This review focuses on how cells regulate the level of fatty acids by these systems. RECENT FINDINGS: Ubiquitin regulatory X domain-containing protein 8 has been identified as a specific sensor for unsaturated fatty acids that regulates lipogenic activity. SUMMARY: Together with the previously identified peroxisome proliferator-activated receptors and liver X receptor, these proteins sense the presence of unsaturated fatty acids and initiate reactions preventing their overaccumulation. Understanding the mechanism of the signal transduction pathways mediated by these proteins may offer new strategies to treat metabolic syndrome.

Original languageEnglish (US)
Pages (from-to)118-124
Number of pages7
JournalCurrent Opinion in Lipidology
Volume25
Issue number2
DOIs
StatePublished - Apr 2014

Keywords

  • Fatty acids
  • LXR
  • PPARs
  • SREBP-1
  • UBXD8

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Genetics
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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