Cerebral vasomotor reactivity during hypo-and hypercapnia in sedentary elderly and Masters athletes

Yong Sheng Zhu, Takashi Tarumi, Benjamin Y. Tseng, Dean M. Palmer, Benjamin D. Levine, Rong Zhang

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Physical activity may influence cerebrovascular function. The objective of this study was to determine the impact of life-long aerobic exercise training on cerebral vasomotor reactivity (CVMR) to changes in end-tidal CO2 (EtCO2) in older adults. Eleven sedentary young (SY, 27±5 years), 10 sedentary elderly (SE, 72±4 years), and 11 Masters athletes (MA, 72±6 years) underwent the measurements of cerebral blood flow velocity (CBFV), arterial blood pressure, and EtCO2 during hypocapnic hyperventilation and hypercapnic rebreathing. Baseline CBFV was lower in SE and MA than in SY while no difference was observed between SE and MA. During hypocapnia, CVMR was lower in SE and MA compared with SY (1.87±0.42 and 1.47±0.21 vs. 2.18±0.28 CBFV%/mm Hg, P<0.05) while being lowest in MA among all groups (P<0.05). In response to hypercapnia, SE and MA exhibited greater CVMR than SY (6.00±0.94 and 6.67±1.09 vs. 3.70±1.08 CBFV1%/mm Hg, P<0.05) while no difference was observed between SE and MA. A negative linear correlation between hypo-and hypercapnic CVMR (R 2 =0.37, P<0.001) was observed across all groups. Advanced age was associated with lower resting CBFV and lower hypocapnic but greater hypercapnic CVMR. However, life-long aerobic exercise training appears to have minimal effects on these age-related differences in cerebral hemodynamics.

Original languageEnglish (US)
Pages (from-to)1190-1196
Number of pages7
JournalJournal of Cerebral Blood Flow and Metabolism
Volume33
Issue number8
DOIs
StatePublished - Aug 2013

Fingerprint

Cerebrovascular Circulation
Hypercapnia
Athletes
Blood Flow Velocity
Exercise
Hypocapnia
Hyperventilation
Arterial Pressure
Hemodynamics

Keywords

  • aging
  • cerebral perfusion
  • exercise
  • transcranial Doppler

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

Cite this

Cerebral vasomotor reactivity during hypo-and hypercapnia in sedentary elderly and Masters athletes. / Zhu, Yong Sheng; Tarumi, Takashi; Tseng, Benjamin Y.; Palmer, Dean M.; Levine, Benjamin D.; Zhang, Rong.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 33, No. 8, 08.2013, p. 1190-1196.

Research output: Contribution to journalArticle

Zhu, Yong Sheng ; Tarumi, Takashi ; Tseng, Benjamin Y. ; Palmer, Dean M. ; Levine, Benjamin D. ; Zhang, Rong. / Cerebral vasomotor reactivity during hypo-and hypercapnia in sedentary elderly and Masters athletes. In: Journal of Cerebral Blood Flow and Metabolism. 2013 ; Vol. 33, No. 8. pp. 1190-1196.
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