Abstract
Background: Younger age, male sex and presence of spinal cord lesion(s) increase the risk of conversion from radiologically isolated syndrome (RIS) to relapsing-remitting multiple sclerosis (RRMS). Elevated cerebrospinal fluid (CSF) chitinase-3-like protein 1 (CHI3L1) levels predict conversion from clinically isolated syndrome (CIS) to RRMS. Objective: To evaluate the prognostic value of CSF CHI3L1 in RIS patients for conversion to RRMS. Methods: We compared CSF CHI3L1 concentrations in RIS, CIS, RRMS and symptomatic controls (SCs). We analysed the influence of epidemiological, radiological and CSF parameters on the risk of clinical event. Results: A total of 211 patients (71 RIS, 48 CIS, 50 RRMS and 42 SC) were included. CSF CHI3L1 levels were lower in RIS than in RRMS and higher in RIS with positive CSF versus negative CSF and SC. The presence of at least one spinal cord lesion was the only independent predictor of faster conversion to RRMS. Association of high CSF CHI3L1 levels, positive CSF (presence of oligoclonal bands and/or an elevated IgG index) or four Barkhof criteria with any spinal cord lesion showed a tendency for reduced mean conversion time. Conclusion: CSF CHI3L1 correlates with positive CSF but is not an independent predictor of the risk of conversion from RIS to RRMS.
| Original language | English (US) |
|---|---|
| Journal | Multiple Sclerosis Journal |
| DOIs | |
| State | Accepted/In press - Mar 1 2018 |
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Keywords
- biomarkers
- cerebrospinal fluid
- diagnosis
- Multiple sclerosis
- prognosis
- radiologically isolated syndrome
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Cerebrospinal fluid chitinase-3-like protein 1 level is not an independent predictive factor for the risk of clinical conversion in radiologically isolated syndrome. / Thouvenot, Eric; Hinsinger, Geoffrey; Demattei, Christophe; Uygunoglu, Ugur; Castelnovo, Giovanni; Pittion-Vouyovitch, Sophie; Okuda, Darin; Kantarci, Orhun; Pelletier, Daniel; Lehmann, Sylvain; Marin, Philippe; Siva, Aksel; Lebrun, Christine.
In: Multiple Sclerosis Journal, 01.03.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cerebrospinal fluid chitinase-3-like protein 1 level is not an independent predictive factor for the risk of clinical conversion in radiologically isolated syndrome
AU - Thouvenot, Eric
AU - Hinsinger, Geoffrey
AU - Demattei, Christophe
AU - Uygunoglu, Ugur
AU - Castelnovo, Giovanni
AU - Pittion-Vouyovitch, Sophie
AU - Okuda, Darin
AU - Kantarci, Orhun
AU - Pelletier, Daniel
AU - Lehmann, Sylvain
AU - Marin, Philippe
AU - Siva, Aksel
AU - Lebrun, Christine
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Background: Younger age, male sex and presence of spinal cord lesion(s) increase the risk of conversion from radiologically isolated syndrome (RIS) to relapsing-remitting multiple sclerosis (RRMS). Elevated cerebrospinal fluid (CSF) chitinase-3-like protein 1 (CHI3L1) levels predict conversion from clinically isolated syndrome (CIS) to RRMS. Objective: To evaluate the prognostic value of CSF CHI3L1 in RIS patients for conversion to RRMS. Methods: We compared CSF CHI3L1 concentrations in RIS, CIS, RRMS and symptomatic controls (SCs). We analysed the influence of epidemiological, radiological and CSF parameters on the risk of clinical event. Results: A total of 211 patients (71 RIS, 48 CIS, 50 RRMS and 42 SC) were included. CSF CHI3L1 levels were lower in RIS than in RRMS and higher in RIS with positive CSF versus negative CSF and SC. The presence of at least one spinal cord lesion was the only independent predictor of faster conversion to RRMS. Association of high CSF CHI3L1 levels, positive CSF (presence of oligoclonal bands and/or an elevated IgG index) or four Barkhof criteria with any spinal cord lesion showed a tendency for reduced mean conversion time. Conclusion: CSF CHI3L1 correlates with positive CSF but is not an independent predictor of the risk of conversion from RIS to RRMS.
AB - Background: Younger age, male sex and presence of spinal cord lesion(s) increase the risk of conversion from radiologically isolated syndrome (RIS) to relapsing-remitting multiple sclerosis (RRMS). Elevated cerebrospinal fluid (CSF) chitinase-3-like protein 1 (CHI3L1) levels predict conversion from clinically isolated syndrome (CIS) to RRMS. Objective: To evaluate the prognostic value of CSF CHI3L1 in RIS patients for conversion to RRMS. Methods: We compared CSF CHI3L1 concentrations in RIS, CIS, RRMS and symptomatic controls (SCs). We analysed the influence of epidemiological, radiological and CSF parameters on the risk of clinical event. Results: A total of 211 patients (71 RIS, 48 CIS, 50 RRMS and 42 SC) were included. CSF CHI3L1 levels were lower in RIS than in RRMS and higher in RIS with positive CSF versus negative CSF and SC. The presence of at least one spinal cord lesion was the only independent predictor of faster conversion to RRMS. Association of high CSF CHI3L1 levels, positive CSF (presence of oligoclonal bands and/or an elevated IgG index) or four Barkhof criteria with any spinal cord lesion showed a tendency for reduced mean conversion time. Conclusion: CSF CHI3L1 correlates with positive CSF but is not an independent predictor of the risk of conversion from RIS to RRMS.
KW - biomarkers
KW - cerebrospinal fluid
KW - diagnosis
KW - Multiple sclerosis
KW - prognosis
KW - radiologically isolated syndrome
UR - http://www.scopus.com/inward/record.url?scp=85044723531&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044723531&partnerID=8YFLogxK
U2 - 10.1177/1352458518767043
DO - 10.1177/1352458518767043
M3 - Article
C2 - 29564952
AN - SCOPUS:85044723531
JO - Multiple Sclerosis
JF - Multiple Sclerosis
SN - 1352-4585
ER -