Cerebrospinal fluid concentrations of corticotropin-releasing hormone (CRH) and diazepam-binding inhibitor (DBI) during alcohol withdrawal and abstinence

Bryon Adinoff, Ray Anton, Markku Linnoila, Alessandra Guidotti, Charles B. Nemeroff, Garth Bissette

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

The neuropeptides diazepam binding inhibitor (DBI) and corticotropin-releasing hormone (CRH) elicit anxiety-like symptoms when administered intracerebroventricularly to laboratory animals. Because of the similarities between the symptoms of certain anxiety states and the alcohol withdrawal syndrome, we hypothesized that increased secretion of either of these endogenous neuropeptides may at least in part, be responsible for the symptoms of alcohol withdrawal. We therefore measured DBI and CRH concentrations in cerebrospinal fluid (CSF) of 15 alcohol-dependent patients during acute withdrawal (Day 1) and again at 3 week's abstinence (Day 21). In addition, plasma concentrations of cortisol were measured to evaluate the relationship between pituitary-adrenal axis activation and CSF CRH concentrations. CSF CRH (p < .04), but not CSF DBI, was significantly higher on Day 1 than on Day 21. Although there was a significant decrease in plasma cortisol from Day 1 to Day 21 (p < .001), a significant correlation between CSF CRH and plasma cortisol concentrations was not observed at either time point. Neither CSF neutropeptide correlated with clinical measures of withdrawal severity. These tentative findings may implicate CRH, but not DBI, in the pathogenesis of alcohol withdrawal. Alternately, the central release of CRH and DBI may not be adequately reflected in lumbar CSF.

Original languageEnglish (US)
Pages (from-to)288-295
Number of pages8
JournalNeuropsychopharmacology
Volume15
Issue number3
DOIs
StatePublished - Sep 1996

Keywords

  • Alcohol withdrawal
  • Alcoholism
  • Corticotropin releasing hormone
  • Diazepam binding inhibitor
  • GABA receptor
  • HPA axis

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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