TY - JOUR
T1 - Cerebro‐spinal Fluid Studies in Alcoholics and Violent Offenders
AU - Nutt, David
AU - Adinoff, Bryon
AU - Ravitz, Bernard
AU - George, Ted
AU - Risher‐Flowers, Debra
AU - Eckardt, Michael
AU - Bone, George
AU - Martin, Peter
AU - Linnoila, Markku
PY - 1988/1
Y1 - 1988/1
N2 - Abstract: Firstly, the contribution that cerebro‐spinal fluid (CSF) studies have made to our understanding of the pathophysiology of alcohol withdrawal is addressed. Secondly, the developing literature, from our own studies and those of others, on abnormal CSF measurements in alcoholics and violent offenders is reviewed, with particular regard to impulsive murderers and arsonists. It is concluded that there is CSF evidence for increased norepinephrine function in alcohol withdrawal and an underlying serotonin hypofunction in impulsive disorders including some forms of alcoholism. Finally we report that patients with Korsakoff's syndrome may have central serotonin dysfunction since they show memory improvements during treatment with the serotonin uptake blocker fluvoxamine. Furthermore, these improvements correlate with the magnitude of change that fluvoxamine produces in CSF concentrations of the serotonin metabolite 5‐HIAA. 1988 Australasian Professional Society on Alcohol and other Drugs
AB - Abstract: Firstly, the contribution that cerebro‐spinal fluid (CSF) studies have made to our understanding of the pathophysiology of alcohol withdrawal is addressed. Secondly, the developing literature, from our own studies and those of others, on abnormal CSF measurements in alcoholics and violent offenders is reviewed, with particular regard to impulsive murderers and arsonists. It is concluded that there is CSF evidence for increased norepinephrine function in alcohol withdrawal and an underlying serotonin hypofunction in impulsive disorders including some forms of alcoholism. Finally we report that patients with Korsakoff's syndrome may have central serotonin dysfunction since they show memory improvements during treatment with the serotonin uptake blocker fluvoxamine. Furthermore, these improvements correlate with the magnitude of change that fluvoxamine produces in CSF concentrations of the serotonin metabolite 5‐HIAA. 1988 Australasian Professional Society on Alcohol and other Drugs
KW - Catecholamines
KW - alcohol amnestic disorder
KW - methoxyhydroxyphenylglycol
KW - serotonin
KW - violence
UR - http://www.scopus.com/inward/record.url?scp=84990616990&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84990616990&partnerID=8YFLogxK
U2 - 10.1080/09595238880000231
DO - 10.1080/09595238880000231
M3 - Article
AN - SCOPUS:84990616990
SN - 0819-5331
VL - 7
SP - 105
EP - 108
JO - Australian Drug and Alcohol Review
JF - Australian Drug and Alcohol Review
IS - 1
ER -