Cerebrovascular autoregulation and neurologic injury in neonatal hypoxic-ischemic encephalopathy

Jessica A. Howlett, Frances J. Northington, Maureen M. Gilmore, Aylin Tekes, Thierry A.G.M. Huisman, Charlamaine Parkinson, Shang En Chung, Jacky M. Jennings, Jessica J. Jamrogowicz, Abby C. Larson, Christoph U. Lehmann, Eric Jackson, Ken M. Brady, Raymond C. Koehler, Jennifer K. Lee

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Background:Neonates with hypoxic-ischemic encephalopathy (HIE) are at risk of cerebral blood flow dysregulation. Our objective was to describe the relationship between autoregulation and neurologic injury in HIE.Methods:Neonates with HIE had autoregulation monitoring with the hemoglobin volume index (HVx) during therapeutic hypothermia, rewarming, and the first 6 h of normothermia. The 5-mm Hg range of mean arterial blood pressure (MAP) with best vasoreactivity (MAP OPT) was identified. The percentage of time spent with MAP below MAP OPT and deviation in MAP from MAP OPT were measured. Neonates received brain magnetic resonance imaging (MRI) 3-7 d after treatment. MRIs were coded as no, mild, or moderate/severe injury in five regions.Results:HVx identified MAP OPT in 79% (19/24), 77% (17/22), and 86% (18/21) of the neonates during hypothermia, rewarming, and normothermia, respectively. Neonates with moderate/severe injury in paracentral gyri, white matter, basal ganglia, and thalamus spent a greater proportion of time with MAP below MAP OPT during rewarming than neonates with no or mild injury. Neonates with moderate/severe injury in paracentral gyri, basal ganglia, and thalamus had greater MAP deviation below MAP OPT during rewarming than neonates without injury.Conclusion:Maintaining MAP within or above MAP OPT may reduce the risk of neurologic injuries in neonatal HIE.

Original languageEnglish (US)
Pages (from-to)525-535
Number of pages11
JournalPediatric Research
Volume74
Issue number5
DOIs
StatePublished - Nov 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Howlett, J. A., Northington, F. J., Gilmore, M. M., Tekes, A., Huisman, T. A. G. M., Parkinson, C., Chung, S. E., Jennings, J. M., Jamrogowicz, J. J., Larson, A. C., Lehmann, C. U., Jackson, E., Brady, K. M., Koehler, R. C., & Lee, J. K. (2013). Cerebrovascular autoregulation and neurologic injury in neonatal hypoxic-ischemic encephalopathy. Pediatric Research, 74(5), 525-535. https://doi.org/10.1038/pr.2013.132