Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review

Henrik Hellquist, Alena Skálová, Leon Barnes, Antonio Cardesa, Lester D.R. Thompson, Asterios Triantafyllou, Michelle D. Williams, Kenneth O. Devaney, Douglas R. Gnepp, Justin A. Bishop, Bruce M. Wenig, Carlos Suárez, Juan P. Rodrigo, Andrés Coca-Pelaz, Primož Strojan, Jatin P. Shah, Marc Hamoir, Patrick J. Bradley, Carl E. Silver, Pieter J. SlootwegVincent Vander Poorten, Afshin Teymoortash, Jesus E. Medina, K. Thomas Robbins, Karen T. Pitman, Luiz P. Kowalski, Remco de Bree, William M. Mendenhall, Jean Anderson Eloy, Robert P. Takes, Alessandra Rinaldo, Alfio Ferlito

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC–HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this review: searching for all published cases of AdCC-HGT. We conclude that it is mandatory to perform elective neck dissection in patients with AdCC-HGT, due to the high risk of lymph node metastases associated with transformation.

Original languageEnglish (US)
Pages (from-to)357-368
Number of pages12
JournalAdvances in Therapy
Volume33
Issue number3
DOIs
StatePublished - Mar 1 2016

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Keywords

  • Adenoid cystic carcinoma
  • Dedifferentiation
  • Fatal outcome
  • High-grade transformation
  • Local recurrence
  • Lymphatic metastasis
  • Neck dissection
  • Neoplasm recurrence
  • Salivary glands

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Hellquist, H., Skálová, A., Barnes, L., Cardesa, A., Thompson, L. D. R., Triantafyllou, A., Williams, M. D., Devaney, K. O., Gnepp, D. R., Bishop, J. A., Wenig, B. M., Suárez, C., Rodrigo, J. P., Coca-Pelaz, A., Strojan, P., Shah, J. P., Hamoir, M., Bradley, P. J., Silver, C. E., ... Ferlito, A. (2016). Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review. Advances in Therapy, 33(3), 357-368. https://doi.org/10.1007/s12325-016-0298-5