Changes in amount and intracellular distribution of androgen receptor in human foreskin as a function of age

Claus Roehrborn, J. L. Lange, F. W. George, J. D. Wilson

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

To provide insight into the factors that control growth of the penis we measured the amount and intracellular distibution of specific high affinity androgen receptor in foreskins obtained at circumcision from 49 males varying in age from newborn to 59 yr. Total (cytosolic plus nuclear extract) androgen receptor decreased from ~40 fmol/g tissue weight in newborn foreskins to ~25 fmol/g by 1 yr of age. The amount of receptor rose in childhood to ~180 fmol/g in the late teenage years and fell thereafter to ~20-40 fmol/g in men older than 40 yr. The amount of receptor in the nuclear fraction increased at the time of puberty and subsequently decreased in parallel with the decline in total receptor level. These changes in androgen-receptor amount are similar when expressed per milligram DNA or per milligram protein.

Original languageEnglish (US)
Pages (from-to)44-47
Number of pages4
JournalJournal of Clinical Investigation
Volume79
Issue number1
StatePublished - 1987

Fingerprint

Foreskin
Androgen Receptors
Newborn Infant
Male Circumcision
Penis
Puberty
Cytoplasmic and Nuclear Receptors
Intercellular Signaling Peptides and Proteins
Weights and Measures
DNA
human AR protein
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Changes in amount and intracellular distribution of androgen receptor in human foreskin as a function of age. / Roehrborn, Claus; Lange, J. L.; George, F. W.; Wilson, J. D.

In: Journal of Clinical Investigation, Vol. 79, No. 1, 1987, p. 44-47.

Research output: Contribution to journalArticle

@article{5cf44570bd52418a81262635511143b5,
title = "Changes in amount and intracellular distribution of androgen receptor in human foreskin as a function of age",
abstract = "To provide insight into the factors that control growth of the penis we measured the amount and intracellular distibution of specific high affinity androgen receptor in foreskins obtained at circumcision from 49 males varying in age from newborn to 59 yr. Total (cytosolic plus nuclear extract) androgen receptor decreased from ~40 fmol/g tissue weight in newborn foreskins to ~25 fmol/g by 1 yr of age. The amount of receptor rose in childhood to ~180 fmol/g in the late teenage years and fell thereafter to ~20-40 fmol/g in men older than 40 yr. The amount of receptor in the nuclear fraction increased at the time of puberty and subsequently decreased in parallel with the decline in total receptor level. These changes in androgen-receptor amount are similar when expressed per milligram DNA or per milligram protein.",
author = "Claus Roehrborn and Lange, {J. L.} and George, {F. W.} and Wilson, {J. D.}",
year = "1987",
language = "English (US)",
volume = "79",
pages = "44--47",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "The American Society for Clinical Investigation",
number = "1",

}

TY - JOUR

T1 - Changes in amount and intracellular distribution of androgen receptor in human foreskin as a function of age

AU - Roehrborn, Claus

AU - Lange, J. L.

AU - George, F. W.

AU - Wilson, J. D.

PY - 1987

Y1 - 1987

N2 - To provide insight into the factors that control growth of the penis we measured the amount and intracellular distibution of specific high affinity androgen receptor in foreskins obtained at circumcision from 49 males varying in age from newborn to 59 yr. Total (cytosolic plus nuclear extract) androgen receptor decreased from ~40 fmol/g tissue weight in newborn foreskins to ~25 fmol/g by 1 yr of age. The amount of receptor rose in childhood to ~180 fmol/g in the late teenage years and fell thereafter to ~20-40 fmol/g in men older than 40 yr. The amount of receptor in the nuclear fraction increased at the time of puberty and subsequently decreased in parallel with the decline in total receptor level. These changes in androgen-receptor amount are similar when expressed per milligram DNA or per milligram protein.

AB - To provide insight into the factors that control growth of the penis we measured the amount and intracellular distibution of specific high affinity androgen receptor in foreskins obtained at circumcision from 49 males varying in age from newborn to 59 yr. Total (cytosolic plus nuclear extract) androgen receptor decreased from ~40 fmol/g tissue weight in newborn foreskins to ~25 fmol/g by 1 yr of age. The amount of receptor rose in childhood to ~180 fmol/g in the late teenage years and fell thereafter to ~20-40 fmol/g in men older than 40 yr. The amount of receptor in the nuclear fraction increased at the time of puberty and subsequently decreased in parallel with the decline in total receptor level. These changes in androgen-receptor amount are similar when expressed per milligram DNA or per milligram protein.

UR - http://www.scopus.com/inward/record.url?scp=0023119507&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023119507&partnerID=8YFLogxK

M3 - Article

C2 - 3491838

AN - SCOPUS:0023119507

VL - 79

SP - 44

EP - 47

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 1

ER -