Changes in glucagon levels after four to five weeks of glucoregulation by portable insulin infusion pumps

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Near-normal glucoregulation was maintained in five patients with juvenile-onset diabetes mellitus for 4-5 wk with a preprogrammed, continuous, subcutaneous insulin infusion using a portable battery-powered infusion pump. This form of therapy significantly lowered immunoreactive glucagon (IRG) levels below those observed while on conventional insulin treatment at several times during the 24-h profile. The maximum IRG levels were also reduced in all five subjects. Thus, a flexible system of insulin delivery, as is provided by certain open-loop pump systems, can overcome inappropriate glucagon secretion that occurs with conventional insulin therapy.

Original languageEnglish (US)
Pages (from-to)1033-1035
Number of pages3
Issue number11
Publication statusPublished - 1979


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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