Channel-like function of the Na,K pump probed at microsecond resolution in giant membrane patches

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151 Citations (Scopus)

Abstract

Ion transporters can be thought of as ion channels that open and close only at one end at a time. As in real channels, ions may cross through an electrical field as they diffuse into and bind within the transporter pore, thereby generating electrical current. Extracellular sodium binding by the sodium potassium (Na,K) pump is associated with ultrafast charge movements in giant cardiac membrane patches. The charge movements are complete within 4 microseconds. They occur only when binding sites are open to the extracellular side, and they are abolished by ouabain and by the removal of extracellular sodium. Fast extracellular ion binding may be the exclusive source of Na,K pump electrogenicity.

Original languageEnglish (US)
Pages (from-to)1429-1432
Number of pages4
JournalScience
Volume263
Issue number5152
StatePublished - Mar 11 1994

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Sodium
Ion Channels
Membranes
Ions
Ouabain
Potassium
Binding Sites

ASJC Scopus subject areas

  • General

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Channel-like function of the Na,K pump probed at microsecond resolution in giant membrane patches. / Hilgemann, Donald W.

In: Science, Vol. 263, No. 5152, 11.03.1994, p. 1429-1432.

Research output: Contribution to journalArticle

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