Characterization of a diguanylate cyclase from Shewanella woodyi with cyclase and phosphodiesterase activities

Niu Liu, Taemee Pak, Elizabeth M. Boon

Research output: Contribution to journalArticlepeer-review

Abstract

Cyclic-di-GMP signaling is used by many bacteria to control biofilm formation. As biofilm formation is an important survival strategy for many bacteria, the synthesis and degradation of cyclic-di-GMP is tightly regulated by enzymes containing domains with conserved GGDEF and EAL sequence motifs, respectively. In this report we characterize a protein with both cyclase and phosphodiesterase activities and demonstrate that it contributes to secretion of the extracellular polysaccharide matrix, an important step in early biofilm formation.

Original languageEnglish (US)
Pages (from-to)1561-1564
Number of pages4
JournalMolecular BioSystems
Volume6
Issue number9
DOIs
StatePublished - Sep 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology

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