Characterization of the spontaneous murine B cell leukemia (BCL 1). III. Evidence for monoclonality by using an anti-idiotype antibody

E. S. Vitetta, D. Yuan, K. Krolick, P. Isakson, M. Knapp, S. Slavin, S. Strober

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

The authors have raised an anti-idiotypic antibody against the cell surface IgM of the murine BCL 1 tumor cells. This antiserum reacts exclusively with the IgM expressed on the tumor cells and detects a unique population of cells in the spleen and blood of the tumor-bearing mice. When these cells are stimulated in vitro with LPS, they secrete an IgM bearing the same idiotype as the cell surface Ig. These results are discussed in terms of a model for the immunotherapy of a chronic lymphocytic leukemia-like syndrome in mice.

Original languageEnglish (US)
Pages (from-to)1649-1654
Number of pages6
JournalJournal of Immunology
Volume122
Issue number5
StatePublished - Dec 27 1979

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Characterization of the spontaneous murine B cell leukemia (BCL <sub>1</sub>). III. Evidence for monoclonality by using an anti-idiotype antibody'. Together they form a unique fingerprint.

  • Cite this