Characterization of the spontaneous murine B cell leukemia (BCL 1). III. Evidence for monoclonality by using an anti-idiotype antibody

E. S. Vitetta, D. Yuan, K. Krolick, P. Isakson, M. Knapp, S. Slavin, S. Strober

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The authors have raised an anti-idiotypic antibody against the cell surface IgM of the murine BCL 1 tumor cells. This antiserum reacts exclusively with the IgM expressed on the tumor cells and detects a unique population of cells in the spleen and blood of the tumor-bearing mice. When these cells are stimulated in vitro with LPS, they secrete an IgM bearing the same idiotype as the cell surface Ig. These results are discussed in terms of a model for the immunotherapy of a chronic lymphocytic leukemia-like syndrome in mice.

Original languageEnglish (US)
Pages (from-to)1649-1654
Number of pages6
JournalJournal of Immunology
Volume122
Issue number5
StatePublished - 1979

Fingerprint

B-Cell Leukemia
Anti-Idiotypic Antibodies
Immunoglobulin M
Neoplasms
B-Cell Chronic Lymphocytic Leukemia
Immunotherapy
Immune Sera
Spleen
Population

ASJC Scopus subject areas

  • Immunology

Cite this

Characterization of the spontaneous murine B cell leukemia (BCL 1). III. Evidence for monoclonality by using an anti-idiotype antibody. / Vitetta, E. S.; Yuan, D.; Krolick, K.; Isakson, P.; Knapp, M.; Slavin, S.; Strober, S.

In: Journal of Immunology, Vol. 122, No. 5, 1979, p. 1649-1654.

Research output: Contribution to journalArticle

Vitetta, ES, Yuan, D, Krolick, K, Isakson, P, Knapp, M, Slavin, S & Strober, S 1979, 'Characterization of the spontaneous murine B cell leukemia (BCL 1). III. Evidence for monoclonality by using an anti-idiotype antibody', Journal of Immunology, vol. 122, no. 5, pp. 1649-1654.
Vitetta, E. S. ; Yuan, D. ; Krolick, K. ; Isakson, P. ; Knapp, M. ; Slavin, S. ; Strober, S. / Characterization of the spontaneous murine B cell leukemia (BCL 1). III. Evidence for monoclonality by using an anti-idiotype antibody. In: Journal of Immunology. 1979 ; Vol. 122, No. 5. pp. 1649-1654.
@article{316355b4922e454da5f1a591be31837c,
title = "Characterization of the spontaneous murine B cell leukemia (BCL 1). III. Evidence for monoclonality by using an anti-idiotype antibody",
abstract = "The authors have raised an anti-idiotypic antibody against the cell surface IgM of the murine BCL 1 tumor cells. This antiserum reacts exclusively with the IgM expressed on the tumor cells and detects a unique population of cells in the spleen and blood of the tumor-bearing mice. When these cells are stimulated in vitro with LPS, they secrete an IgM bearing the same idiotype as the cell surface Ig. These results are discussed in terms of a model for the immunotherapy of a chronic lymphocytic leukemia-like syndrome in mice.",
author = "Vitetta, {E. S.} and D. Yuan and K. Krolick and P. Isakson and M. Knapp and S. Slavin and S. Strober",
year = "1979",
language = "English (US)",
volume = "122",
pages = "1649--1654",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "5",

}

TY - JOUR

T1 - Characterization of the spontaneous murine B cell leukemia (BCL 1). III. Evidence for monoclonality by using an anti-idiotype antibody

AU - Vitetta, E. S.

AU - Yuan, D.

AU - Krolick, K.

AU - Isakson, P.

AU - Knapp, M.

AU - Slavin, S.

AU - Strober, S.

PY - 1979

Y1 - 1979

N2 - The authors have raised an anti-idiotypic antibody against the cell surface IgM of the murine BCL 1 tumor cells. This antiserum reacts exclusively with the IgM expressed on the tumor cells and detects a unique population of cells in the spleen and blood of the tumor-bearing mice. When these cells are stimulated in vitro with LPS, they secrete an IgM bearing the same idiotype as the cell surface Ig. These results are discussed in terms of a model for the immunotherapy of a chronic lymphocytic leukemia-like syndrome in mice.

AB - The authors have raised an anti-idiotypic antibody against the cell surface IgM of the murine BCL 1 tumor cells. This antiserum reacts exclusively with the IgM expressed on the tumor cells and detects a unique population of cells in the spleen and blood of the tumor-bearing mice. When these cells are stimulated in vitro with LPS, they secrete an IgM bearing the same idiotype as the cell surface Ig. These results are discussed in terms of a model for the immunotherapy of a chronic lymphocytic leukemia-like syndrome in mice.

UR - http://www.scopus.com/inward/record.url?scp=0018425865&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018425865&partnerID=8YFLogxK

M3 - Article

C2 - 109513

AN - SCOPUS:0018425865

VL - 122

SP - 1649

EP - 1654

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 5

ER -