Chemokine-enhanced migration of human peripheral blood mononuclear cells is antagonized by interferon beta-1b through an effect on matrix metalloproteinase-9

Olaf Stuve; Sophie Chabot; Sonia S. Jung; Gary Williams; Voon Wee Yong

doi:10.1016/S0165-5728(97)00134-3

Chemokine-enhanced migration of human peripheral blood mononuclear cells is antagonized by interferon beta-1b through an effect on matrix metalloproteinase-9

Olaf Stuve, Sophie Chabot, Sonia S. Jung, Gary Williams, Voon Wee Yong

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

The increased migration of peripheral blood mononuclear cells (PBMNCs) across a fibronectin (FN) matrix in response to the chemokines RANTES, MIP- 1α and MCP-1 is antagonized by interferon beta-1b (IFN β-1b): MCP-1 treatment of PBMNCs elevates their mRNA level and secretion of a matrix degrading enzyme, matrix metalloproteinase (MMP)-9, which is abrogated by IFN β-1b. The clinical benefits of IFN β-1b treatment in multiple sclerosis patients may in part be a result of this drug's ability to decrease the migration of PBMNCs in spite of a chemotactic gradient. Furthermore, the elevation of MMP-9 production by PBMNCs may be an important mechanism of action of chemokines.

Original language	English (US)
Pages (from-to)	38-46
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	80
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-5728(97)00134-3
State	Published - Dec 1997

Keywords

Cell trafficking
Extracellular matrix
Lymphocyte
Multiple sclerosis

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/S0165-5728(97)00134-3

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title = "Chemokine-enhanced migration of human peripheral blood mononuclear cells is antagonized by interferon beta-1b through an effect on matrix metalloproteinase-9",

abstract = "The increased migration of peripheral blood mononuclear cells (PBMNCs) across a fibronectin (FN) matrix in response to the chemokines RANTES, MIP- 1α and MCP-1 is antagonized by interferon beta-1b (IFN β-1b): MCP-1 treatment of PBMNCs elevates their mRNA level and secretion of a matrix degrading enzyme, matrix metalloproteinase (MMP)-9, which is abrogated by IFN β-1b. The clinical benefits of IFN β-1b treatment in multiple sclerosis patients may in part be a result of this drug's ability to decrease the migration of PBMNCs in spite of a chemotactic gradient. Furthermore, the elevation of MMP-9 production by PBMNCs may be an important mechanism of action of chemokines.",

keywords = "Cell trafficking, Extracellular matrix, Lymphocyte, Multiple sclerosis",

author = "Olaf Stuve and Sophie Chabot and Jung, {Sonia S.} and Gary Williams and Yong, {Voon Wee}",

note = "Funding Information: This work was supported by a research grant from Berlex Laboratories, Richmond, CA. O.S. was supported by a postdoctoral fellowship from the Deutsche Forschungsgemeinschaft (STU 208/2-1).",

year = "1997",

month = dec,

doi = "10.1016/S0165-5728(97)00134-3",

language = "English (US)",

volume = "80",

pages = "38--46",

journal = "Journal of Neuroimmunology",

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T1 - Chemokine-enhanced migration of human peripheral blood mononuclear cells is antagonized by interferon beta-1b through an effect on matrix metalloproteinase-9

AU - Stuve, Olaf

AU - Chabot, Sophie

AU - Jung, Sonia S.

AU - Williams, Gary

AU - Yong, Voon Wee

N1 - Funding Information: This work was supported by a research grant from Berlex Laboratories, Richmond, CA. O.S. was supported by a postdoctoral fellowship from the Deutsche Forschungsgemeinschaft (STU 208/2-1).

PY - 1997/12

Y1 - 1997/12

N2 - The increased migration of peripheral blood mononuclear cells (PBMNCs) across a fibronectin (FN) matrix in response to the chemokines RANTES, MIP- 1α and MCP-1 is antagonized by interferon beta-1b (IFN β-1b): MCP-1 treatment of PBMNCs elevates their mRNA level and secretion of a matrix degrading enzyme, matrix metalloproteinase (MMP)-9, which is abrogated by IFN β-1b. The clinical benefits of IFN β-1b treatment in multiple sclerosis patients may in part be a result of this drug's ability to decrease the migration of PBMNCs in spite of a chemotactic gradient. Furthermore, the elevation of MMP-9 production by PBMNCs may be an important mechanism of action of chemokines.

AB - The increased migration of peripheral blood mononuclear cells (PBMNCs) across a fibronectin (FN) matrix in response to the chemokines RANTES, MIP- 1α and MCP-1 is antagonized by interferon beta-1b (IFN β-1b): MCP-1 treatment of PBMNCs elevates their mRNA level and secretion of a matrix degrading enzyme, matrix metalloproteinase (MMP)-9, which is abrogated by IFN β-1b. The clinical benefits of IFN β-1b treatment in multiple sclerosis patients may in part be a result of this drug's ability to decrease the migration of PBMNCs in spite of a chemotactic gradient. Furthermore, the elevation of MMP-9 production by PBMNCs may be an important mechanism of action of chemokines.

KW - Cell trafficking

KW - Extracellular matrix

KW - Lymphocyte

KW - Multiple sclerosis

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U2 - 10.1016/S0165-5728(97)00134-3

DO - 10.1016/S0165-5728(97)00134-3

M3 - Article

C2 - 9413258

AN - SCOPUS:0031471371

SN - 0165-5728

VL - 80

SP - 38

EP - 46

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Chemokine-enhanced migration of human peripheral blood mononuclear cells is antagonized by interferon beta-1b through an effect on matrix metalloproteinase-9

Abstract

Keywords

ASJC Scopus subject areas

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