Chemokine-enhanced migration of human peripheral blood mononuclear cells is antagonized by interferon beta-1b through an effect on matrix metalloproteinase-9

Olaf Stuve, Sophie Chabot, Sonia S. Jung, Gary Williams, Voon Wee Yong

Research output: Contribution to journalArticle

96 Scopus citations

Abstract

The increased migration of peripheral blood mononuclear cells (PBMNCs) across a fibronectin (FN) matrix in response to the chemokines RANTES, MIP- 1α and MCP-1 is antagonized by interferon beta-1b (IFN β-1b): MCP-1 treatment of PBMNCs elevates their mRNA level and secretion of a matrix degrading enzyme, matrix metalloproteinase (MMP)-9, which is abrogated by IFN β-1b. The clinical benefits of IFN β-1b treatment in multiple sclerosis patients may in part be a result of this drug's ability to decrease the migration of PBMNCs in spite of a chemotactic gradient. Furthermore, the elevation of MMP-9 production by PBMNCs may be an important mechanism of action of chemokines.

Original languageEnglish (US)
Pages (from-to)38-46
Number of pages9
JournalJournal of Neuroimmunology
Volume80
Issue number1-2
DOIs
StatePublished - Dec 1 1997

Keywords

  • Cell trafficking
  • Extracellular matrix
  • Lymphocyte
  • Multiple sclerosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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