Chemoradiotherapy of human tumors: Novel approaches from nanomedicine

Michael Edward Werner, Michael Bonner Foote, Andrew Zhuang Wang

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Chemoradiotherapy is an important treatment paradigm in oncology and is part of the curative treatment for many solid cancers, such as lung, pancreatic and cervical cancers. One of the main goals in oncology research is to develop approaches that can improve the efficacy of chemoradiotherapy while minimizing treatment toxicity. A new and exciting approach is to incorporate advances in nanomedicine into chemoradiotherapy. Nanoparticles possess unique properties, such as preferential accumulation in tumors and minimal uptake in normal tissues, that make them ideally suited for delivering chemotherapy in chemoradiotherapy. In this review, we plan to discuss the rationale and evidence for applying nanomedicine to chemoradiotherapy.

Original languageEnglish (US)
Pages (from-to)2830-2837
Number of pages8
JournalCurrent Pharmaceutical Design
Volume18
Issue number19
DOIs
StatePublished - Jun 2012
Externally publishedYes

Keywords

  • Chemoradiation
  • Chemoradiation nanoparticles
  • Nanomedicine
  • Nanoparticle chemoradiotherapy
  • Nanoparticle radiosensitization
  • Nanoparticle radiosensitizer
  • Nanoparticle radiotherapy
  • Translational nanomedicine

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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