Chemotherapy and irradiation interaction

Hak Choy, Dong W. Kim

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The combination of chemotherapeutic drugs with radiation therapy has perhaps been one of the most promising strategies for current cancer radiotherapy practice, and has a strong biologic rationale. Concurrent chemoradiotherapy has been shown to improve survival and locoregional control of various cancers compared with radiotherapy alone. This article reviews the biologic rationale and principles fundamental to the use of chemoradiotherapy, and discusses mechanistic interactions between drugs and radiation, the knowledge of which is essential in developing optimal treatment strategies. Chemotherapeutic agents, particularly those shown to augment the radiation response of tumors, will be reviewed, and novel compounds and some of the exciting emerging strategies for chemoradiotherapy will be presented.

Original languageEnglish (US)
Pages (from-to)3-10
Number of pages8
JournalSeminars in oncology
Volume30
Issue number4 SUPPL. 9
DOIs
StatePublished - Aug 2003

ASJC Scopus subject areas

  • Hematology
  • Oncology

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