Chikungunya-induced cell death is limited by ER and oxidative stress-induced autophagy

Pierre Emmanuel Joubert, Scott Werneke, Claire De La Calle, Florence Guivel-Benhassine, Alessandra Giodini, Lucie Peduto, Beth Levine, Olivier Schwartz, Deborah Lenschow, Matthew L. Albert

Research output: Contribution to journalShort survey

20 Scopus citations

Abstract

It has been recognized that macroautophagy constitutes an important survival mechanism that allows both the maintenance of cellular homeostasis and the regulation of programmed cell death pathways (e.g., apoptosis). Although several pathogens have been described to induce autophagy, the prosurvival function of this process in infectious models remains poorly characterized. Our recent studies on chikungunya virus (CHIKV), the causative agent of major epidemics in India, Southeast Asia and southern Europe, reveal a novel mechanism by which autophagy limits the cytopathic effects of CHIKV by impinging upon virus-induced cell death pathways.

Original languageEnglish (US)
Pages (from-to)1261-1263
Number of pages3
JournalAutophagy
Volume8
Issue number8
DOIs
StatePublished - Aug 2012

Keywords

  • Apoptosis
  • Autophagy
  • Chikungunya
  • Endoplasmic reticulum stress and oxidative stress

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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    Joubert, P. E., Werneke, S., De La Calle, C., Guivel-Benhassine, F., Giodini, A., Peduto, L., Levine, B., Schwartz, O., Lenschow, D., & Albert, M. L. (2012). Chikungunya-induced cell death is limited by ER and oxidative stress-induced autophagy. Autophagy, 8(8), 1261-1263. https://doi.org/10.4161/auto.20751