Childhood adversity increases vulnerability for behavioral symptoms and immune dysregulation in women with breast cancer

Linda Witek Janusek, Dina Tell, Kevin Albuquerque, Herbert L. Mathews

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Women respond differentially to the stress-associated with breast cancer diagnosis and treatment, with some women experiencing more intense and/or sustained behavioral symptoms and immune dysregulation than others. Childhood adversity has been identified to produce long-term dysregulation of stress response systems, increasing reactivity to stressors encountered during adulthood. This study determined whether childhood adversity increased vulnerability for more intense and sustained behavioral symptoms (fatigue, perceived stress, and depressive symptoms), poorer quality of life, and greater immune dysregulation in women (. N=. 40) with breast cancer. Evaluation was after breast surgery and through early survivorship. Hierarchical linear modeling was used to examine intra-individual and inter-individual differences with respect to initial status and to the pattern of change (i.e. trajectory) of outcomes. At initial assessment, women exposed to childhood emotional neglect/abuse had greater perceived stress, fatigue, depressive symptoms and poorer quality of life, as well as lower natural killer cell activity (NKCA). Although these outcomes improved over time, women with greater childhood emotional neglect/abuse exhibited worse outcomes through early survivorship. No effect was observed on the pattern of change for these outcomes. In contrast, childhood physical neglect predicted sustained trajectories of greater perceived stress, worse quality of life, and elevated plasma IL-6; with no effect observed at initial assessment. Thus, childhood adversity leaves an enduring imprint, increasing vulnerability for behavioral symptoms, poor quality of life, and elevations in IL-6 in women with breast cancer. Further, childhood adversity predisposes to lower NKCA at a critical time when this immune-effector mechanism is most effective at halting nascent tumor seeding.

Original languageEnglish (US)
JournalBrain, Behavior, and Immunity
Volume30
Issue numberSUPPL.
DOIs
StatePublished - Mar 15 2013

Fingerprint

Behavioral Symptoms
Breast Neoplasms
Quality of Life
Natural Killer Cells
Fatigue
Interleukin-6
Survival Rate
Depression
Individuality
Breast
Neoplasms

Keywords

  • Breast cancer
  • Childhood adversity
  • Childhood emotional neglect/abuse
  • Childhood physical neglect/abuse
  • Depression
  • Fatigue
  • IL-6
  • Natural killer cell activity
  • Perceived stress
  • Quality of life

ASJC Scopus subject areas

  • Immunology
  • Behavioral Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Childhood adversity increases vulnerability for behavioral symptoms and immune dysregulation in women with breast cancer. / Witek Janusek, Linda; Tell, Dina; Albuquerque, Kevin; Mathews, Herbert L.

In: Brain, Behavior, and Immunity, Vol. 30, No. SUPPL., 15.03.2013.

Research output: Contribution to journalArticle

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